Hi,
A little different for myself , my own hormones started changing about 21 years ago . in prep for becoming a woman so what little the added hormones have done is just what is normal for a menopausle woman for health reasons, so HRT = E. was about 10 years ago .
as for Spiro my body rejected them , so was not on them long ,
as some of us are different the synthic meds dont allways work for every one ,
...noeleena...