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Questions about goserelin/zoladex and dutasteride

Started by mitan, October 01, 2014, 04:02:37 AM

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mitan

hii

i have been on spiro/dutasteride/estradiol for 1.5 years self medicating and now i am getting prescribed properlly on NHS in the uk. i have had my first goserelin injection but they didn't prescribe me any DHT blocker, just goserelin/estradiol. is it not necessary to take a dht blocker when on this medication? it slipped my mind to ask when at the gender clinic and my next appointment is in 2 months. does anybody know?

i was pretty happy about my results from self medicating i had minor hairloss before but im happy with it now and it hasnt changed in years i just  rly dont want to get worse if i stop dht blocker for this medication
i would really appreciate if anyone can help me know more about this ^^

thx!
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Flan

After an initial flare effect (that lasts a couple days) it effectively shuts down gonad hormone production. Adrenal hormone production shouldn't be enough to necessitate a secondary anti-hormone med.
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kira21 ♡♡♡

It is my understanding that DHT is still manufactured in the scalp though, from remaining T, which is what dutasteride blocks through 5-alpha-reductase inhibition, so if you have MPB it would be an idea to discuss it with your endo. Really you need to be having the discussion with your endo though.

mitan

thank yuu Flan and kira21 for helping me! i spoke to person at gender clinic about it im now taking leuprorelin because the goserelin injections are too scary and i spoke to them about the dht blocker and they hafe perscibed me dutasteride and my last blood tests from this had good results so im very happy everything is being good now!

thanks~
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Clhoe G

leuprorelin is a very powerful castration drug, it will literally kill your libido, n totally prevent the ability to get erect, it's so powerful because it's a puberty blocker too, it works by shutting down the LH, FSH and pituitary GnRH receptors, it even blocks estradiol in males, I personally wouldn't go near the stuff, I use bicalutamide n dutasteride, because it doesn't mess with all that stuff, it just blocks the effects of testosterone on my body.

Testosterone really shouldn't be completely annihilated, just put into female range, because testosterone deficiency can cause problems.

If an anti androgen like, cyproterone, bicalutamide and flutamide is taken with an LH, FSH agonist they will have the same effect as leuprorelin, triptorelin and goserelin, they will cause full chemical castration n totally annihilate testosterone at the source, they use to use these drugs to forcefully castrate transsexuals as a requirement of transitioning, for an example this requirement was only lifted in Sweden in 2013 they also had to have srs and have all banked sperm destroyed, just to get female on I.D or birth certificates before 2013 and other countries have been little better, so be carefully many doctors are still in favor of this method, the exact same method that labeled a transsexuals gender dysphoria as a illness/disorder and sexual deviancy, just like they labeled homosexuality and I don't know how much you know about this, but homosexuality use to be illegal, but they allowed for people to become transsexual despite this, meaning total castration of them/us, plus pre-op transsexual marriage was n still is illegal in most places, unless you have no kids n have had srs, like seriously there has been very little change n it only all started to change not so long ago, it's all political crap.

This should probably be in a different thread...
history of discrimination, I should put that thread in, I looked into a lot of it before I started HRT.
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Wow, I could have sworn I've been on HRT for longer.
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kitten_lover

Quote from: Clhoe G on December 02, 2014, 06:35:18 AM
leuprorelin is a very powerful castration drug, it will literally kill your libido, n totally prevent the ability to get erect, it's so powerful because it's a puberty blocker too, it works by shutting down the LH, FSH and pituitary GnRH receptors, it even blocks estradiol in males, I personally wouldn't go near the stuff, I use bicalutamide n dutasteride, because it doesn't mess with all that stuff, it just blocks the effects of testosterone on my body.

Testosterone really shouldn't be completely annihilated, just put into female range, because testosterone deficiency can cause problems.

If an anti androgen like, cyproterone, bicalutamide and flutamide is taken with an LH, FSH agonist they will have the same effect as leuprorelin, triptorelin and goserelin, they will cause full chemical castration n totally annihilate testosterone at the source, they use to use these drugs to forcefully castrate transsexuals as a requirement of transitioning, for an example this requirement was only lifted in Sweden in 2013 they also had to have srs and have all banked sperm destroyed, just to get female on I.D or birth certificates before 2013 and other countries have been little better, so be carefully many doctors are still in favor of this method, the exact same method that labeled a transsexuals gender dysphoria as a illness/disorder and sexual deviancy, just like they labeled homosexuality and I don't know how much you know about this, but homosexuality use to be illegal, but they allowed for people to become transsexual despite this, meaning total castration of them/us, plus pre-op transsexual marriage was n still is illegal in most places, unless you have no kids n have had srs, like seriously there has been very little change n it only all started to change not so long ago, it's all political crap.

This should probably be in a different thread...
history of discrimination, I should put that thread in, I looked into a lot of it before I started HRT.

Hi Chloe,

I hope your still using this website...as you sound quite knowledgable on this particular subject I am concerned with. I am currenlty on triptorelin and have found it difficult... for the most part mentally, but also the physical effects haven't been as successful as when I were taking spironolactone. The NHS in the UK will not prescribe spiro and since I am finding it hard to cope on the current antiandrogen given to me, I was going to raise with my endo or GP that I'd like to try leuproprepin or gosrelin acetate, have u had any experience with these? My libido has decreased massively, i just feel disinterested in life. My t levels are in the right range and my e levels aren't high enough. I will also ask for an increase in estradiol but I have been on this dosage before and previous to taking triptorelin i had felt fine. The only option I can think of is to try a different antiandrogen.  i am keen to go the full way with SRS and don't want my penis, but having a low libido all my life shifts the balance of that decision, somewhat.

Can anyone else who has taken the antiandrogens mentioned above describe the mental effects they have experienced, please?
"The opposite of courage in our society is not cowardice...it is conformity."                  ~ Rollo May, Man's Search for Himself.
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