The only real issue for me is fear of being unable to access it at some point, due to funds or something else. A once a week shot is no biggie.
Paraphrasing something I read awhile back:
If a doctor told you that you had a bacterial infection that could never be cured, only controlled through treatment, and you had to administer treatment at least twice a day for two minutes - AND you would periodically require longer, professional treatments - or an important part of your digestive system would slowly be destroyed and possibly start a chain reaction of other health maladies, what would you think of that?
But chances are you probably brush your teeth and think nothing of it. It's just something you have to do to be healthy.