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Peaks and Troughs With Injectable Estradiol?

Started by Wynternight, December 22, 2014, 10:08:37 AM

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Wynternight

I gave myself my first dose of injectable estrasiol Saturday and today I feel awful. Today is one of the "staring into the abyss" days I used to get when the patches began to wear off a few days before changing them. Is this normal? Will I feel like this on and off on the injectable because if so, I don't know if I can take this.
Stooping down, dipping my wings, I came into the darkly-splendid abodes. There, in that formless abyss was I made a partaker of the Mysteries Averse. LIBER CORDIS CINCTI SERPENTE-11;4

HRT- 31 August, 2014
FT - 7 Sep, 2016
VFS- 19 October, 2016
FFS/BA - 28 Feb, 2018
SRS - 31 Oct 2018
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Mariah

I haven't noticed anything like that. The only thing I have noticed as I get in the last 2 or 3 days before the next shot is I tend be a bit more moody. It will be interesting see if that changes with the dose being lowered slightly starting with my next shot. You might want to contact the doctor who prescribed and let them know what your seeing. He or she may have a solution for it.
Mariah
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KayXo

Best to give it some more time before making any drastic changes...I personally felt better with injectables. Depends on how much you're taking and how it compares to what you were taking before...and hopefully, it was well injected, deep enough into muscle...
I am not a medical doctor, nor a scientist - opinions expressed by me on the subject of HRT are merely based on my own review of some of the scientific literature over the last decade or so, on anecdotal evidence from women in various discussion forums that I have come across, and my personal experience

On HRT since early 2004
Post-op since late 2005
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Jenna Marie

I felt like that on weekly patches... and found out that the generics especially only delivered the full dose for ~4 days of that week. I switched to twice weekly and haven't had a problem since. Anyway, it makes sense that if you're sensitive to the troughs of estrogen, injections might trigger the same response as the dose wears off.
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Wynternight

The weekly patches were awful. I eventually changed to the Vivelle dots, the twice a week patches but I'm getting rashes from the patches so I went to the IM. I'm hoping today is a fluke because I really feel awful.
Stooping down, dipping my wings, I came into the darkly-splendid abodes. There, in that formless abyss was I made a partaker of the Mysteries Averse. LIBER CORDIS CINCTI SERPENTE-11;4

HRT- 31 August, 2014
FT - 7 Sep, 2016
VFS- 19 October, 2016
FFS/BA - 28 Feb, 2018
SRS - 31 Oct 2018
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Ms Grace

Is that awful physically or emotionally? I honestly can't remember how I felt after my first injection and I also can't remember how often I was getting them (it was over twenty years ago after all) but I do remember being on a real emotional rollercoaster. I do think I felt physically OK though. See how you feel after the next dose and maybe see the doc if it doesn't seem to be getting any better.
Grace
----------------------------------------------
Transition 1.0 (Julie): HRT 1989-91
Self-denial: 1991-2013
Transition 2.0 (Grace): HRT June 24 2013
Full-time: March 24, 2014 :D
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Wynternight

Quote from: Ms Grace on December 22, 2014, 03:32:30 PM
Is that awful physically or emotionally? I honestly can't remember how I felt after my first injection and I also can't remember how often I was getting them (it was over twenty years ago after all) but I do remember being on a real emotional rollercoaster. I do think I felt physically OK though. See how you feel after the next dose and maybe see the doc if it doesn't seem to be getting any better.

Emotionally. I feel almost as bad as I did before starting HRT. I haven't felt this hollow inside in a long time and it's worse right now since I have felt better. I'm glad I'm at work and around people right now.
Stooping down, dipping my wings, I came into the darkly-splendid abodes. There, in that formless abyss was I made a partaker of the Mysteries Averse. LIBER CORDIS CINCTI SERPENTE-11;4

HRT- 31 August, 2014
FT - 7 Sep, 2016
VFS- 19 October, 2016
FFS/BA - 28 Feb, 2018
SRS - 31 Oct 2018
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Ms Grace

Take care of yourself. I know that feeling, it's not great, I would cry at the slightest provocation. I didn't realise the injections were largely behind it and apparently it's what many genetic women experience when they go through their cycle. Not fun. Will you have someone to be with after work?
Grace
----------------------------------------------
Transition 1.0 (Julie): HRT 1989-91
Self-denial: 1991-2013
Transition 2.0 (Grace): HRT June 24 2013
Full-time: March 24, 2014 :D
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Wynternight

Quote from: Ms Grace on December 22, 2014, 04:52:50 PM
Take care of yourself. I know that feeling, it's not great, I would cry at the slightest provocation. I didn't realise the injections were largely behind it and apparently it's what many genetic women experience when they go through their cycle. Not fun. Will you have someone to be with after work?

I have a session of electro and it's home to an empty flat afterwards.
Stooping down, dipping my wings, I came into the darkly-splendid abodes. There, in that formless abyss was I made a partaker of the Mysteries Averse. LIBER CORDIS CINCTI SERPENTE-11;4

HRT- 31 August, 2014
FT - 7 Sep, 2016
VFS- 19 October, 2016
FFS/BA - 28 Feb, 2018
SRS - 31 Oct 2018
  •  

Ms Grace

Please take care - I know that electro usually lowers my moods even on good days. Is there anyone you can talk to?
Grace
----------------------------------------------
Transition 1.0 (Julie): HRT 1989-91
Self-denial: 1991-2013
Transition 2.0 (Grace): HRT June 24 2013
Full-time: March 24, 2014 :D
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Wynternight

Quote from: Ms Grace on December 22, 2014, 05:16:24 PM
Please take care - I know that electro usually lowers my moods even on good days. Is there anyone you can talk to?

I'd be terrified I today was upper lip day as that always puts me through the emotional wringer but today's my chin. I can call mum when I get home. We talk nightly but I think I'll need some more support given how I feel right now.
Stooping down, dipping my wings, I came into the darkly-splendid abodes. There, in that formless abyss was I made a partaker of the Mysteries Averse. LIBER CORDIS CINCTI SERPENTE-11;4

HRT- 31 August, 2014
FT - 7 Sep, 2016
VFS- 19 October, 2016
FFS/BA - 28 Feb, 2018
SRS - 31 Oct 2018
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Rachel

I was in a 14 day IM schedule of delestrogen, the high concentration. At day 10 I felt a slight lull that became worse as time passed to a low on the 14th day.( this occurred for 6 injections). I asked and now am on a 10 day schedule as of last Tuesday.


Just finished laser and will need to schedule electrolysis. Does electro hurt more than laser on the upper lip? If so I do not know how I will take it.
HRT  5-28-2013
FT   11-13-2015
FFS   9-16-2016 -Spiegel
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Hair Grafts 3-20-2017 - Cooley
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Wynternight

Quote from: Cynthia Michelle on December 22, 2014, 07:27:55 PM
I was in a 14 day IM schedule of delestrogen, the high concentration. At day 10 I felt a slight lull that became worse as time passed to a low on the 14th day.( this occurred for 6 injections). I asked and now am on a 10 day schedule as of last Tuesday.


Just finished laser and will need to schedule electrolysis. Does electro hurt more than laser on the upper lip? If so I do not know how I will take it.

My hair was too light for laser so I can't compare the two but I have found the upper lip to be the most painful, by far.
Stooping down, dipping my wings, I came into the darkly-splendid abodes. There, in that formless abyss was I made a partaker of the Mysteries Averse. LIBER CORDIS CINCTI SERPENTE-11;4

HRT- 31 August, 2014
FT - 7 Sep, 2016
VFS- 19 October, 2016
FFS/BA - 28 Feb, 2018
SRS - 31 Oct 2018
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KayXo

Let yourself feel that emptiness or dull feeling and perhaps hidden in that, lies something that may shed a light on something. Don't always run away from the bad because sometimes the bad can bring forth important realizations that allow one to grow. Anyways, that's what I've learned through my 10 yr transition...
I am not a medical doctor, nor a scientist - opinions expressed by me on the subject of HRT are merely based on my own review of some of the scientific literature over the last decade or so, on anecdotal evidence from women in various discussion forums that I have come across, and my personal experience

On HRT since early 2004
Post-op since late 2005
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Wynternight

Quote from: KayXo on December 22, 2014, 09:27:27 PM
Let yourself feel that emptiness or dull feeling and perhaps hidden in that, lies something that may shed a light on something. Don't always run away from the bad because sometimes the bad can bring forth important realizations that allow one to grow. Anyways, that's what I've learned through my 10 yr transition...

I've been feeling that my whole life. I'm sick of feeling it. It's worse now that I know I don't need to feel that way. I'm ready for some good.
Stooping down, dipping my wings, I came into the darkly-splendid abodes. There, in that formless abyss was I made a partaker of the Mysteries Averse. LIBER CORDIS CINCTI SERPENTE-11;4

HRT- 31 August, 2014
FT - 7 Sep, 2016
VFS- 19 October, 2016
FFS/BA - 28 Feb, 2018
SRS - 31 Oct 2018
  •  

Newgirl Dani

Wynternight,

I surely hope this helps.  There are times when dark has to get darker before light can come.

There are two parts to this answer: One is physical and the other may be emotional (where the above line comes in), at times they are connected.

In response to the emotional, you may want to very carefully read KayXo's post about when surgeries and hormones CAN'T help.  I say this because sometimes the one thing we need most is one thing we 'continue' to never see, and with every ounce of our being, the one we sometimes 'refuse' to see.  Many here have suffered in many different ways, and a fair number of times it came about when we were very young.  This is a time when we are looking for that stability for our welfare to come from an outside source (as it should be) because we have not gained enoungh personal power to accomplish this for ourselves.  There are a myriad of hurts, disappointments, and many can and do stem from a physical disconnect through no fault of our own.  Add to this awful mix a powerful urge to just want to fit in and we have a recipe for many types of disaster on the personality front.  All too often these get buried under many many layers of 'fixes' of our own making (again, as it should be).  As years go by the walls of our little world get plastered with innumerable pics that keep our mental and psychological well being 'safe'.  These can be very hard to chip away, very hard indeed, and with each one, an old pain is re-lived.
  In my own case, this is the reason I kept myself on the precipice of death for amost three and a half decades through drug use that bordered on insanity.  With all that said, I guess maybe the best way to put this is, at this juncture in our lives, no matter the age, we need to read certain posts as we NEED to, rather than how we WANT to read them.  For me personally, I am forever picking up gems that people have thrown onto my path.

In regards to the physical, well even though I had this above task to attend to, I also had to experiment with injection cycle periods. I ultimately settled into a seven day cycle.  I posted the very same thing as you just did not all that long ago.  My experience took me to the edge of quitting the forum, quitting all contact with people....and more.  At 63, this kind of thing was NOT welcome, but the valley of each trough brought me just a little closer to healing because it allowed that 'viewpoint' for me to see.   Yesterday, I all out cried......for the first time.    If you, or anyone needs to talk, PM me, and I will be here.   Dani

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Wynternight

Thank you all. I'm feeling a bit better today. I suppose I just need time for my body to adapt to the new medication. I got home from electro last night and spent hours in conversation with a friend via Yahoo, talked to my mum, and played a gane until bed so I was well and truly distracted.
Stooping down, dipping my wings, I came into the darkly-splendid abodes. There, in that formless abyss was I made a partaker of the Mysteries Averse. LIBER CORDIS CINCTI SERPENTE-11;4

HRT- 31 August, 2014
FT - 7 Sep, 2016
VFS- 19 October, 2016
FFS/BA - 28 Feb, 2018
SRS - 31 Oct 2018
  •  

Randi

With injectables, such as estradiol valerate the level tends to smooth out after a while.

I think the half-life of the injection is around 8 days.  If you take a shot today, it will peak tomorrow and your levels will fall to half after a little more than a week.  The remnants of that first shot will fall to 1/4 in 16 days, 1/8 in 24 days and 1/16 in 32 days etc.

After you have taken a series of shots the latest one will have the greatest effect, but you will still be getting an effect from those earlier shots.  The result will that that after a few months of regular injections you will have much steadier levels.

If your doctor has you on shots every 2 weeks, see if he will allow you to take half the dose every week.
   
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Wynternight

Quote from: Randi on December 23, 2014, 01:00:35 PM
With injectables, such as estradiol valerate the level tends to smooth out after a while.

I think the half-life of the injection is around 8 days.  If you take a shot today, it will peak tomorrow and your levels will fall to half after a little more than a week.  The remnants of that first shot will fall to 1/4 in 16 days, 1/8 in 24 days and 1/16 in 32 days etc.

After you have taken a series of shots the latest one will have the greatest effect, but you will still be getting an effect from those earlier shots.  The result will that that after a few months of regular injections you will have much steadier levels.

If your doctor has you on shots every 2 weeks, see if he will allow you to take half the dose every week.


I'm on a 10 day cycle. I was considering doing a half dose Q5 days if the 10 day cycle isn't helping my mood.
Stooping down, dipping my wings, I came into the darkly-splendid abodes. There, in that formless abyss was I made a partaker of the Mysteries Averse. LIBER CORDIS CINCTI SERPENTE-11;4

HRT- 31 August, 2014
FT - 7 Sep, 2016
VFS- 19 October, 2016
FFS/BA - 28 Feb, 2018
SRS - 31 Oct 2018
  •  

Peebles

Oh yeah I feel a difference. I get an injection every two weeks and a definitely feel a change throughout the two weeks.

My best guess is that is goes something like this:
-Get the injection, get like euphoria for a few days
-I think it peaks some time by week two and I'll be all weepy and crying over stupid ->-bleeped-<-
-By the time i need my injection again I feel kinda drained and tired

that's just me personally, I imagine other people might vary wildly
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