A very cool couple I knew in high school stuck together after one of them discovered she was MTF and began transitioning. Her girlfriend was very loving and accepting and was always bisexual and had no problem with the idea or the actual changes. Many years later they are still a very happy couple and I'm proud of them both for being wonderful and happy people!
I had no idea how my parents were going to react, as well as fairly religious family members. My very christian middle american relatives in Ohio seemed to really not care at all which surprised me. They are, in hindsight very laid back and loving, responsible people. It's lovely to know there are conservative and religious people who can actually do as Jesus said and love thy neighbor and refrain from judging and condemning. I feel even very conservative people do not have to be upset by trans or queer people when they understand they are also just people. I appreciate everyone needs to express themselves and be who they are, but it helps that there is much more info out in our world about average normal people who just happen to be a little different. The internet is really great for exposing us to new points of view. Also, as many awful and ignorant people and violent events as there are, I think a good deal of people are realizing it's not really that big of a deal to be trans or queer. Even in the 50s there were people like Kinsey who were trying to make it clear that human sexuality and gender was a spectrum rather than any kind of cut and dry black and white situation!