I learned the hard lesson after wife #1 to be more open about my gender issues. I wish I could say it was for the better. I had a fiance that I told before we got engaged. As wedding date pressure mounted from family, she broke. She called things off because I was not a "Real man".
BTW - I've really come to hate hearing the phrase "You're not like other guys" from women.
My current wife of many decades also knew of my GD from day 1. She was supportive to a point. Glad I had no plans for transitioning back then, that I got that out of my system with my prior experiments. SHe eventually even stayed around the apartment those Sundays I needed my escape from maleness. Being a devout sexist, her seeing me presenting as female affected her. For days afterwards forget intimacy of any sort. All she could see was Joanne, not John.
When I needed to drop the T-Bomb on her six years ago, it went a bit better then I thought it would. In her near suicidal state as it was, she didn't off herself, or me. It was a major struggle on both our parts to keep the relationship going. For me it was wrestling with this demon I so wanted to keep locked away forever, but couldn't. For her it was the typical shock, the feelings of being lied to, betrayal, blaming herself for wanting to believe it would never happen, the very real chance I'd dump her and run off with one of my MTF support group members or some guy.
Today I still hear the occassional "I did not marry a woman" along with the new "I can't think of you as my husband with those bumps on your chest". Yet on balance many more basic things about me changed for the better. Her love for me perhaps stronger then ever with the personal growth I achieved as I am finally becoming one whole and complete person.
You can't change who people are. You two can either grow together or grow apart. Each of us need to balance all our life priorities, needs and desires. Or, as I put it, Which Pain is Worse.