Do anti androgens combined with estrogen reduce androgens in the long run

[Monika1223]

Ok so I hope my questions is clear.  I am wondering if one takes estrogen and anti androgens for let's say a year or more and then stops the anti androgens. Does that reduce the overall amount of androgens the body will produce? As opposed to only taking estrogen without any anti androgens.

Because anti androgens by themselves work until you stop them. And then all the effects they had reverse. But does taking estrogen along with anti androgens reduce the overall production of testosterone and androgens once you stop taking anti androgens?

Hope someone knows. Thanks.

[Mariah]

Your doctor would be the best to ask this question to. Having said it will differ from person to person. Lots of factors are at play and I won't speculate as to how your body or anybody including mine would react to that idea. The delivery method, the type of hormone, and the type of anti androgen's along with the doses, your genetics, metabolism, and health come into play. Hugs
Mariah

[Monika1223]

Your doctor would be the best to ask this question to. Having said it will differ from person to person. Lots of factors are at play and I won't speculate as to how your body or anybody including mine would react to that idea. The delivery method, the type of hormone, and the type of anti androgen's along with the doses, your genetics, metabolism, and health come into play. Hugs
Mariah

Thanks. So it's not as simple as I thought. 
You're right I will have to ask an endocrinologist as well.

[Randi]

Estrogen alone will greatly reduce production of testosterone after a while.  For many people an anti-androgen is not necessary.  An anti-androgen may speed up the process, but it is not necessary in all cases.

[katrinaw]

It does depend on age apart from how your body works... I agree with Mariah, consult with your Endo/Dr because we all vary so much.

Having said that, as a male it is unlikely that E alone will reduce the production of T unless you have had Orchiectomy or GRS/SRS... But that is all IMHO, a non medic.

L Katy 

[Laura_7]

Estrogen alone will greatly reduce production of testosterone after a while.  For many people an anti-androgen is not necessary.  An anti-androgen may speed up the process, but it is not necessary in all cases.

There are people who take estrogen and progesterone via implants, without further anti androgen.
The route of intake: topical, injections or implants also plays a role.

hugs

[Monika1223]

I just recently started Premarin. Feels like it's pretty powerful.
And I had an orchiectomy 2 years ago. I won't need anti androgens but I was just curious about how they work.

[luna nyan]

Long term it is likely.

I am on a pellet that is effectively half what my endo would give someone transitioning, but my E levels are around 600.   T is effectively 0 (0.2 last check), and I have been off spiro for about 9 months.

[Laura_7]

I just recently started Premarin. Feels like it's pretty powerful.
And I had an orchiectomy 2 years ago. I won't need anti androgens but I was just curious about how they work.

You might think about bioidentical estrogen.
Otherwise components are present which are not bioidentical with the human body.
https://www.susans.org/forums/index.php/topic,164628.msg1423124.html#msg1423124
Another advantage of micronized estrogen is a sublingual intake. Its supposed to be less straining on the liver and less causing clotting factors.

A further idea is to take for example four small doses of estrogen instead of one or two big ones daily. It might keep levels more steady and help with mood swings.

And you might think about bioidentical progesterone.
https://www.susans.org/forums/index.php/topic,189460.msg1687219.html#msg1687219

Both are available as implants.


Some people even use very small amounts of t after srs or an orchi, in the form of implants or topical for example.
Menopausal women use this, too.
It might help with drive and orgasm capacity, for example after srs.

You should talk this all through with your endo.


hugs

[KayXo]

Once testicles are removed, the only androgen remaining is from adrenal glands, VERY little, less than pre-menopausal women so this should not be an issue. Premarin is contraindicated as it increases clotting risk to a greater extent than bio-identical estradiol, you should discuss this matter with your doctor.

[Monika1223]

Once testicles are removed, the only androgen remaining is from adrenal glands, VERY little, less than pre-menopausal women so this should not be an issue. Premarin is contraindicated as it increases clotting risk to a greater extent than bio-identical estradiol, you should discuss this matter with your doctor.

Hmmm yes I have to get one first.

[Laura_7]

Hmmm yes I have to get one first.

You might ask a gyn...

another possibility would be to look up endos, or ask gyns for an endo... gyns often work together with endos, for obvious reasons...


hugs