And in my experience, it's pretty hard to get the mainstream publishers to accept even mild queer content. It's a shame, and it's something I and other author friends of mine are battling against, but... if your goal is to make yourself more attractive to a larger press, it's unlikely that labeling yourself as a trans woman author will help. (It might not hurt, but the worst part is, in some situations it *could.* I worry about being pigeonholed now that I saw a Publisher's Weekly review of one of my books [full disclosure, I've also been published with a small press for my novels] that complained that there wasn't any significant lesbian or trans content from "an LGBT author.")
With that said, I don't regret being out, and I think the ranks of kick-ass trans women writers can always stand to increase. 😉 I'm not trying to talk you into any particular decision, just warning against thinking that outing yourself will automatically kick-start your career. The truth is, sometimes nobody knows why lightning strikes, and the total pool of published books is growing larger by the minute. When I want to depress myself, I think about how hard it is to get noticed, period.