Maturitas. 2012 Mar;71(3):248-56."Ovariectomy of rats increases food intake and, concomitantly,
body weight [11] and these effects can be reversed by restoring
physiological levels of estradiol [11]"
"estradiol potentiates the effect of the satiating CCK peptide released from the small
intestine in response to food intake [14,15], while attenuating the
appetite-stimulating potency of the gastric hormone ghrelin [16].
Furthermore, estradiol stimulates anorexigenic POMC/CART activity
and inhibits orexigenic NPY/AgRP neurons in the ARC [17,18]."
"In contrast to estrogen, progesterone itself does not significantly
influence feeding behaviour in ovariectomized rats, except when
administered in non-physiological, pharmacological doses [11].
However, in the presence of estrogen, progesterone does stimulate
appetite and promote weight gain [19]."
"both female rodents and primates eat less
during the estrus phase prior to and following ovulation, when they
are more sexually receptive and active [10]."
"Similarly in the case of women, food intake during the different
phases of the menstrual cycle varies (Fig. 3). Thus, a meta-analysis
revealed that mean food intake is lowest during the periovulatory
phase of the menstrual cycle, when estradiol levels are high [23].
In contrast, a peak in food intake occurs during the premenstrual
period, when progesterone levels are high [23–28]."
"Moreover, binge-eating may be more pronounced during
the premenstrual period [29], a process which may involve low levels
of serotonin in the brain [25]."
"Estradiol stimulates the activity of lipoprotein lipase
(LPL) in femoral adipocytes and lipolysis in abdominal adipocytes
[35], thereby promoting accumulation of gluteo-femoral fat. On
the other hand, estrogen deficiency is associated with enhanced
accumulation of abdominal fat [35]."
"In contrast, most such investigations conclude
that HRT actually lowers weight gain and body fat [76,80,81].
In addition, HRT prevents the shift in fat deposition from the normal
female condition to the more unhealthy central fat depots associated
with the menopausal transition (Fig. 5) [76,82,83]."
"treatment of postmenopausal
women with estrogen enhances LPL activity in the
femoral region and at the same time lipolysis in the abdominal
region, which might promote fat accumulation in the former region
and fat loss from the abdomen [84].
"Interestingly, the route of estrogen
administration may be an important factor in this context, since
one crossover study found less fat gain with transdermal than with
oral administration [85]."
"Progestins are known to stimulate food intake (Fig. 5) [72].
For example, cancer-related cachexia and anorexia and other
forms of malnutrition can be effectively treated with high doses
of megestrol acetate"
"treatment of women with bulimia nervosa with an
antiandrogenic OC containing ethinylestradiol and drospirenone
not only reduces androgen levels, but also attenuates binge eating
and appetite in connection with meals [59]. Furthermore, users of
this particular OC exhibit a small reduction in body weight [75]."
Megestrol acetate, like cyproterone acetate and medroxyprogesterone acetate are progestins of the same class, structurally related to progesterone, called acetylated pregnane derivatives.
Drospirenone is also a progestin, structurally related to testosterone, of a class called ethinylated derivatives. It is anti-androgenic, and antimineralocorticoid like Spironolactone, also structurally related to it.
Endocrine Reviews, April 2013, 34(2):171–208"To avoid confusion in light of current practices, the North American Menopause Society has recommended that the term
progestogen should be used when referring to
progesterone and synthetic progestogens collectively, whereas the name
progestin is specific only to
synthetic progestogens (4)."
Here they consider progesterone, natural and all other progestogens (or progestins) synthetic when really they are all produced in the lab, hence synthetic. Instead, they should say progesterone is BIO-IDENTICAL (identical to what the body produces) while all others aren't.
A quick lesson in endocrinology.