Quote from: JoanneB on April 01, 2016, 06:19:58 PM
E probably has more bad complications like DVT, or other blood clotting issues, or Liver shut-downs as well as...
It's important to differentiate between certain forms of non-bio-identical estrogens which have been historically been associated with DVT and liver problems (perhaps) but if she is taking bio-identical estrogen, the risk is quite small as in studies on transsexual women taking moderate to high dose oral E, complications rarely arose (always in association with genetic predisposition/mutation or smoking/obesity), other studies clearly showed Premarin and ethinyl estradiol to be more thrombogenic than oral E which in some cases, didn't even have an effect on clotting. As far as liver goes, E has actually shown to be beneficial in some respects (i.e. fatty liver) and this study...
Hepatol Res. 2007 Apr;37(4):239-47.
Protection of estrogens against the progression of chronic liver disease."Hepatic steatosis was reported to become evident in an aromatase-deficient mouse and was diminished in animals after treatment with estradiol. Our previous studies showed that estradiol suppressed hepatic fibrosis in animal models, and attenuated HSC activation by suppressing the generation of reactive oxygen species in primary cultures."
Non-oral E, even in higher doses given to men of an advanced age (up to 91 yrs old) has shown to have negligible impact on hepatic parameters. And even protect against the risk of thrombosis.
J Urol. 2005 Aug;174(2):527-33; discussion 532-3.
Transdermal estradiol therapy for prostate cancer reduces
thrombophilic activation and protects against thromboembolism."These results suggest that transdermal estradiol reduces
thrombophilic activation in men with advanced prostate cancer, and
protects against the risk of thrombosis."
Prostate 1989;14(4):389-95
Estrogen therapy and liver function--metabolic effects of oral and parenteral
administration."parenteral administration of native estradiol
has very little influence on these aspects of liver function."
J Clin Endocrinol Metab. 1991 Aug;73(2):275-80."despite the relatively high doses necessary to mimic a hormonally normal cycle, the transdermal route did not significantly alter the hepatic parameters studied, suggesting that this route of administration may have less adverse hepatic effects."
Biochem Pharmacol. 2013 Dec 15;86(12):1627-42.
Estrogen, vascular estrogen receptor and hormone therapy in postmenopausal vascular disease."There was no increase in VTE risk with the use of transdermal estrogen, even in patients with pre-existing thrombophilia [15]."
Pregnant women also have very high levels, up to 75,000 pg/ml. Despite this, risk of clotting is extremely low, around 0.05-0.2%. And increases after pregnancy, when levels drop.
Ann Intern Med. 2005 Nov 15;143(10):697-706."Among pregnant women, the highest risk period for venous thromboembolism and pulmonary embolism in particular is during
the postpartum period."
I actually consider bio-identical E to be safer than spironolactone. Half the world population has been on it for millions of years, they don't seem to be dying at a higher rate and even have a longer life expectancy than men.
Quote from: DawnOday on April 01, 2016, 06:41:44 PM
I've been on Spiro since 93 for heart disease, I take it for Congestive Heart Failure. Spiro in heart terms is a diuretic that helps reduce water build up in the pericardium.
Water retention is also increased by insulin and furthermore by carb consumption as this stimulates the release of insulin. Eating less carbs has a potent diuretic effect.
Diabetes March 1990 vol. 39 no. 3 289-298"Because insulin shows an antinatriuretic effect in healthy humans, insulin therapy resulting in circulating hyperinsulinemia may lead to sodium retention and in turn to hypertension in individuals with insulin-dependent diabetes mellitus (IDDM)."
September 1981, Volume 21, Issue 3, pp 165-171"The primary action of insulin on sodium balance is exerted on the kidney. Increases in plasma insulin concentration within the physiological range stimulate sodium reabsorption by the distal nephron segments and this effect is independent of changes in circulating metabolites or other hormones."
Individuals going low carb often find they don't need to take their blood pressure medications anymore.
Pharmaceutical companies don't like too many of us knowing this, hehe.
Now, you know.
