Hello Mariah, I am new to hrt, just 7 weeks in and yet to have any follow up blood work done. Thus I am ignorant of the impact of your numbers. The tangible hormone impacts that I am dealing with are all emotional at this point. I haven't cried this often and for such relatively insignificant things in as long as I can remember! My question is if your e number increase is hitting you emotionally, potential concerns for future health risks or just tracking for a "want to be in range" number. Good luck dealing with the waiting game patience, it seems our trans life has far more waiting game that "Normal" life. Hugs, Anne