Is it possible to become immune to estradiol and spirinolactone?

[Angélique LaCava]

Can't remember if I asked before, but it's something I wonder and worry about.

[kelly_aus]

Nope, not really..

[Jean24]

I had asked a similar question before because I was getting so little out of HRT - and testosterone before it. I have kinda wide hips, and I was always very thin before starting HRT at 27. Since not much had changed, I was starting to really wonder.

[Angélique LaCava]

A few years ago there was a girl on the forums that I'm not sure is still on who said something about her hormones not working anymore. I think her name was Rowan.

[Jean24]

There was a girl on the forums that I'm not sure if is still on who said something about her hormones not working anymore. I think her name was roe.

It is possible. Some people are insensitive to estrogen but it's really rare and she probably would have never had any effects from HRT rather than her having some effects, then having no effects.

[KayXo]

If levels are too steady, tissues may become desensitized, it seems.

[LiliFee]

Perhaps this is one of those typical questions that shouldn't be asked to us lay-people, but to a proper endocrinologist

Having said that, there is anecdotal evidence of desensitization. These are people like us though, who, for better or for worse, have seen their breast growth stalling before the desired result. Whatever. People are inclined to see dragons and monsters where simple solutions exist.

Go and ask your doc, I'm sure there are answers out there. What I do know, is that the human body is a very, VERY complex system and it works differently for each and everyone for us.