Can Changing Dosage Leveld Cause Mood Swings

[MelissaRC]

I have been on M2F HRT for about six months, primarily Spiro and oral Estrodiol. Lately, I have been varying my dosage levels and days taken, for personal reasons. This has been going on for several weeks.

Lately, I have been experiencing mood swings, some depression, etc. I could not figure out why this was happening? Yes, I have personal issues, but they seem exaggerated and unmanagable now.

Is it possible that my varying dosage levels is similar to what a genetic woman might experience during menopause?
Whats next; hot flashes?

this is, btw, a serious questiion with real consequences.

[LizK]

I have been on M2F HRT for about six months, primarily Spiro and oral Estrodiol. Lately, I have been varying my dosage levels and days taken, for personal reasons. This has been going on for several weeks.

Hi Melissa

When I was on my first 2 months of HRT I was taking oral medication increasing to a full transitional dose. During this time I had huge mood swings and yes it is a little disorientating. All this kind of stuff is tied to the levels of hormone in your bloodstream, and trying to keep them on an even basis...

Consult your Dr and tell them how things are for you and they may be able to suggest a better regime or alternative delivery method

Liz

[katiemoz]

Hi Melissa,
It felt that way for me to. I think the HRT step was clouded with fear and doubt for me, partly (or mostly) because I don't fully present female at work. Ugh.  Still, over 2 years, it felt very amazingly right for me, and I think it will for you to. You just need to work past some of the fears and enjoy being you, really you,.


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[KayXo]

Fluctuating levels can sometimes cause mood problems, especially with a significant drop in levels.

[kat69]

I think it's more than possible.  It could have been other factors, but last week I had one of my Estrace pills dissolve in my mouth instead of getting swallowed (I take two in the AM and one at night).   I've read that sublingual estrogen can sometimes lead to a spike.

That day at work, I actually had a crying breakdown, in a meeting with 4 other people in the room.   That's not my normal self....even on hormones.  So....anecdotally I think you could be right. 

[Jenna Marie]

Absolutely. When I complained that I was getting cranky, weepy, and depressed near the end of each week as the patch ran low, my wife and endo (and some other cis female friends!) immediately said I was PMS.   I switched to a twice-weekly patch that kept the E levels steady enough for me, and the symptoms disappeared immediately as long as I stayed on the consistent dose.

Occasionally, I forget to put a new patch on, and then I get irritable or weepy again... even when I don't realize I've forgotten, so it can't be psychosomatic.