In Team Fortress 2, there is a quasi-debate about whether the Pyro is male or female. They wear a baggy fireproof rubber suit and full-face mask, have a vaguely feminine shape if you're looking for it, and all their vocalizations are muffled mumbles (because of the mask) in sort of an alto. And someone has a handbag with a pink daisy on it, though that *could* be anyone's (all the other characters are definitely male). Official posts by the developers have used both pronouns.
Having played a little too much of that game in my time, and often favoring the Pyro... I can easily see a fllamethrower as a good weapon for androgynes.
