About 10 years ago I was diagnosed as hypogonadic, low T. My complaint was that even if I had a full night's sleep if I sat down in a comfortable chair, I couldn't stay awake. I felt lethargic and just couldn't get going. The doctor, when describing my problem and the effects of low T actually said "We're talking about a sex change here". I started testosterone injections.
Well, the Testosterone helped immensely. I began walking, first just around the block and gradually worked up to 5-7 miles at a time. I was going to two consecutive water aerobics classes and then doing a full hour on the elliptical exercise machine.
In addition to the high hemoglobin (thick blood), and in increase in gender dysphoria, I found about aromatase. Aromatase is an enzyme, often present in fat cells. Aromatase converts testosterone to to estradiol, the most potent of estrogens. My estradiol level was 80 on a male scale of 0-50, before I added in an exogenous estradiol.
Six months after starting T, the estradiol kicked in. My nipples were erect all the time, and I could feel my breasts swelling. I've gotta say that growing breasts was a very pleasant experience.
Psychologist Anne Vitale wrote of the effect SOME men experience of increased dysphoria due to testosterone.
http://www.avitale.com/TNote15Testosterone.htm I knew that some sort of sex hormone is necessary for health and well being. Over the next few years, I gradually cut back on the testosterone and began using estrogen. I started with Estrogel and then added in injections of estradiol valerate.
I had my T levels measured a few years later and they were effectively zero. I still take an occasional shot of testosterone. Healthy women have SOME testosterone. Zero is not a good level.
So here I am 10 years after that diagnosis of hypogonadism. I've grown substantial breasts, very little body hair, smooth skin and a butt of nearly Kardashian proportions. I'm mostly bald, and usually dress androgynously. I'm not into makeup and wigs. I've attended a few transexual group meetings. Before I told my story I think many assumed that I was FTM, and I can't blame them.
I should also note that my mother was given DES while carrying me, and I've never felt very male.
I'm not certain that there are any lessons to be learned from my experience. There ARE aromatase inhibitors that are given to women with breast cancer. If I had taken those along with the T, I might have remained male.
The bottom line: Hormones are very powerful and can change your sex.
Randi