Taking Estradiol without Spironolactone? Pros / Cons

[Paige]

Hi,

I'm on low dose E and dutasteride.  I stopped spiro when I started E.  I've been on E for about a year, dutasteride for 2 years.   It does seem to put a small dent in my dysphoria because when I tried to stop it almost drove me crazy.  I've had some breast growth but I can still wear a t-shirt.   I would like my T levels to be lower.  Here's my last test, they're on the low end for a man but too high for a cis-woman.

Testerone is 11.8  nmol/L.  Testosterone Free 175pmol/L.

Hope this is helpful,
Paige

[luna nyan]

Luna - had you been on Spiro at all? Or just E from the beginning? I'm curious and following this thread because I see a day when I'd like to be off Spiro myself.

Started on E (pills) then added Spiro.   When I switched to pellet implant the E levels rose enough and were consistent enough that T has been completely suppressed without Spiro.

I'll be updating my thread soon.

[laurenb]

Thanks Luna. Good information. I believe I read somewhere, and would love to find some clinical verification, that once the T factory is shut down for a while then it doesn't come back while E is present. That's my intent or it's going to have to be an Orchi. I look forward to you updating your thread, BTW. -L

[kelly_aus]

Thanks Luna. Good information. I believe I read somewhere, and would love to find some clinical verification, that once the T factory is shut down for a while then it doesn't come back while E is present. That's my intent or it's going to have to be an Orchi. I look forward to you updating your thread, BTW. -L

http://www.touchoncology.com/articles/androgen-deprivation-therapy-and-re-emergence-parenteral-estrogen-prostate-cancer

[KayXo]

E will bring down T on its own due to negative feedback at the hypothalamus and pituitary gland. As long as there is a decent concentration of sex hormones in the body, regardless of what they may be (P, E or T), the brain stops signalling the testes (or ovaries) to produce sex hormones because it senses there's enough.

Bio-identical estrogen taken non-orally has indeed been shown to be much safer, even in men of a certain age with advanced prostate cancer as the above link attests to. And shown to be effective on its own at reducing T to castrate levels.

[DanaDane]

Long term use of Spiro is very dangerous.   The build of of visceral fat is almost impossible be rid of.  There are other long term uses issues as well and doing a Google search will reveal multiple studies. 

Remember, it was never intended to be what we are using it for.   I don't think it was ever meant for long term use. 

Hi again,

I'm  curious what life might be like just taking Estradiol only?

Just wondering what I'd get out of it alone vs. taking it with Spiro?


I'm wondering? Does Estradiol by itself help promote Hair growth on your head without Spiro? 
Also Wondering how not taking Spiro -  how your Penis , Testicles & Sperm function differently?
Does Taking Estradiol only by itself decrease the probability Breast growth ?

What in Everybody Opinions on here does Spironolactone give you extra for your HRT Regimen ?


Just so ya' know ......I've been on an HRT regimen for about 6 months and have read plenty about what I'm taking I'm
just curious what some of you think threw YOUR Real World Experiences or Some of YOUR Friends Real World Experiences ETC?

Also hoping some Gals on here might be taking Estradiol ONLY and can share their experiences?

Thanks in Advance