Anyone here with antiphospholipid antibody syndrome?

[Daniellekai]

Don't know if I've got that yet, but my mom's got a genetic marker for it, the endocrinologist is looking into if it'll be a problem before scheduling tests, mom was told basically not to use menopausal medications because of clotting risk. It's more rare in men as well, so I think I'll be safe regardless, but I was wondering if anyone knew if it was a contraindication for MTF HRT.

[RavenMoon]

I suppose it would depend on the type of E you are taking? I know some are more problematic than others.


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[Johanna M]

Doctors were i come from prefer gel or patches due to(what they believe) lower effect on coagulation as oral E is processed to a larger extent by the liver then E absorbed through the skin.

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[Dena]

There have been a few posts about people having to quit HRT because of serious clotting issues. The cause wasn't mentioned however this thread might explain the other posts. There is a lab test that can measure clotting factor and you endo may chose to run it while carefully controlling your estrogen dosage. If you don't have the gene, then there shouldn't be an issue with HRT.

[KayXo]

In studies where men, between the ages of 49-91 yrs old, had advanced prostate cancer and thus were more likely to have a thrombosis, the administration of bio-identical estradiol in the form of patches actually reduced a few clotting markers including fibrinogen, D-Dimer and F1+F2 while others remained normal, despite estradiol levels as high as 1,000 pg/ml.

In another study where a few transsexual women had an inherent predisposition to increased clotting, the administration of estradiol in the form of patches did not result in any incidence of thromboembolism.

[Daniellekai]

All clear, I don't have it, got my Spiro and first injection, E seems like a smaller dose and Spiro about mid. Which is what I wanted, low E for the first few months to mimick puberty ramp up, of course don't feel any different yet, other than perhaps a slight improvement in depression.