Quote from: josie76 on September 06, 2017, 07:07:55 AM
My understanding of the action of spironolactone is that it does nothing to shut down The production. It does bind to cellular androgen receptors with an extremely low activation rate thus locking up those receptors so neither T or DHT can get to them. Estrogen HRT is what eventually shuts off the activation hormone at the pituitary so the testes quit production if T. So the point of Spiro is to stop the effects of The on the body while the added HRT slowly turns off the T production.
This is from what I've read as well as the way my endo (professor at Wash U) explained it. His goal was to have enough E to put The into female range. He doesn't even ask for E levels on blood tests.
Since the OP has been on HRT for years it's likely that her current HRT will maintain her surpressed T levels and that the Spiro is no longer needed.
I'm only 6 months on HRT and my T is in the female range but I do want an Orchi so I never have to think about those Things producers again. Also my urologist will do all the notarized papers for me so I can legally change everything.
Thanks I didn't realize this.
My last blood test (a couple weeks ago)
Estradiol 132 pg/mL
Testosterone 24 ng/dL (0-50 is normal female range)
Testosterone, Free, Direct 1.3 pg/mL. (0-0-4.2 is normal range for female)
So since I am producing such little T now (due to the estrogen I guess), I don't really need Spironolactone at all do I?--I mean there isn't really anything to block that is significant. I am going to talk to my endocrinologist about this -- she's taking over my HRT (famiy doctor took care of me for 10 years but he closed down).
Wow I've had T in the 25 range along with Free Testosterone under 1 pg/mL for past 7 years. To think I've been taking this spiro for 10 years for nothing.. geeez! Also I read it interferes with some estrogen receptors? e.g. for breasts? Maybe if I quit this spiro my breast development will improve?
EDIT: I just read in Spiro wikipedia, that Spiro also acts as an androgen production inhibitor. If that is the case maybe I might need it. I could talk to the doc about cutting dose in half for a while and monitor estradiol, T and free T levels. Then keep cutting it down perhaps. I dunno.