To my 15 yo. self: "You don't have to pretend to be anyone else but you can be yourself. You don't have to lie all the time. You can change your name, you can change your gender, you can change your presentation. It's okay and normal to be bisexual. Also Hell isn't real and your dad is a bastard."
To my 17 yo. self: "If you already left you don't have to go back. You can make it on your own. You don't have to live by only lying. It's possible to transition socially, physically, medically. You don't need substances to feel something other than dread. You don't have a limited future, your perspective is limited." [Of course, I really wouldn't tell a minor that isn't me to leave home like I did, but well, leaving was good for me and I shouldn't have tried to return.]
I'm pre-everything so I'm not sure how good the advice I'd give myself would be to anyone else but it's still things I wish I knew at the time. I also don't have the perspective of "always knew" like some trans people but I'm not super binary so maybe it's that.