Kathy Lauren makes a good point. Something to think about, though... What makes being transgender so uncomfortable, so unwanted is not something within ourselves, but in the lack of acceptance by others. Living in a culture that so fervently believes in the heteronormative binary model and shuns any variation from that is where the discomfort, anxiety, and depression comes from. Without that, we'd just be interesting people.
Learning to shed that cultural bias, and finding accepting communities goes a long, long ways towards becoming comfortable and loving ourselves. Oh, in my case I certainly continue to seek out medical care and transition, because I want to feel right in my own body. Still, much of the depression and the self-loathing is gone now.
I very much enjoy being myself, to myself and those around me, for myself. I have my dear friends, so kind and accepting, and I treasure them. I have an accepting community, and I think I have found my path to peace within and joy.
I actually feel sorry for the poor folks so wrapped up and deluded by their cultural bias that they cannot accept even the smallest variations from their cultural binary model. It's sad to think of someone living their life, twisted up, anxious, and angry over every media mention or encounter in life that collides with their very narrow expectations.
Now, mind you, I'm not going to do anything to make these poor souls more comfortable by changing myself. They need help of a rather different kind, but it is difficult to drag an entire culture unwillingly into therapy. They'll have to recognize that they have a problem and accept that change is needed. This will take a while...