Injections or Pills?

[ClaireXO]

I am assuming from the clinic i am going to. They told me that If I wanted injections they'll show me how to self inject. I read so MANY posts about this on this website. I heard that injections are more hard to come by. I heard that you get better results if you use Injections. I am a bit worried of needles.. Should I just do pills first, but I am also a bit worried about my liver. Can you guys give me some advice on this. My appointment on tuesday and I am very very nervous. Can I get some recommendations? I know there is no proof that injections work more efficiently. Thank you <3 (Male to Female)

[2.B.Dana]

I have done pills, patches and am now on injections at my request. I was on a high dose of pills taking them twice a day. I didn't think that was a big deal till I went to one injection a week. It's nice to do it once and forget about it till the next week. There are pro's and con's to every delivery method but the research I did had me leaning towards injections and I am glad I went that route.

[Dena]

If your blood test come back good, there should be no need to worry about your liver. If your uncomfortable with needles, discuss this with your doctor as patches or jells are also an option. The idea it to tailor the treatment so your comfortable with it. If your not comfortable with it, you might skip dosages and that isn't the goal of treatment.

[TinaVane]

I incorporate vitamin b-12 pills/ shots with mines. In the 90's the doctors use to prescribe those to the girls in Florida. Does not seem to be the case anymore
And yes I find shots to be much better

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[Cassi]

Initially, the doctor who prescribed my HRT wanted me to do injections but ain't a big needle fan.  The Endo who took over my HRT has me on the patches which don't work; fall off in two days, ripple up, etc.

Thinking injections would probably be better; quicker and I won't have to worry unless of course I forget.

[MicheleAdams]

The problem is the data to back or refute the liver concerns is scant. It's more of a conclusion to explain correlation than causality data. So I asked some what if it's right and what if it's wrong questions of my doc.

[KayXo]

I heard that you get better results if you use Injections.

I had better results on pills.

Should I just do pills first, but I am also a bit worried about my liver.

Studies have shown no harm to the liver from oral bio-identical estradiol.

[ClaireXO]

I had better results on pills.

Studies have shown no harm to the liver from oral bio-identical estradiol.

Thank you so much! This calms my nerves a bit

[KayXo]

As always, check with your doctor. Don't take anything you hear as gospel. Remain critical.

[ClaireXO]

As always, check with your doctor. Don't take anything you hear as gospel. Remain critical.

Thank you

I got my prescription yesterday. Says, take one estradiol in the morning and 2 spirolactome day/evening (Off the bottle). So, do i need to take the estradiol at the same time every morning. For example, if i take estadiol at 7am today. Tomorrow it has to be at 7am? Just curious

[KathyLauren]

So, do i need to take the estradiol at the same time every morning.

You will get the best results if you maintain a regular schedule.  You want to keep the delivery of estradiol as constant as possible.  Fluctuations in the schedule will cause fluctuations in your blood levels, which can cause mood swings, and can slow down your development.

[Lara]

Have never tried injections. Always been on pills. I don't see any major difference. I personally am thinking of switching to injections.

[KarynMcD]

do i need to take the estradiol at the same time every morning.

Try to, but it's not that critical.

[ClaireXO]

My Doctors Orders was to take Estradiol once a day, every morning. I just began HRT yesterday. Is it normal to take Estradiol once a day. He said he'll bump up the dosage next time I have my appointment which is in 3 months. Obviously, I am going to follow his orders and take it once day. How come some doctors recommend twice day, or does that depend on how long you were on hormones?

[kanad3]

My Doctors Orders was to take Estradiol once a day, every morning. I just began HRT yesterday. Is it normal to take Estradiol once a day. He said he'll bump up the dosage next time I have my appointment which is in 3 months. Obviously, I am going to follow his orders and take it once day. How come some doctors recommend twice day, or does that depend on how long you were on hormones?

It is normal to take once a day. The half life is 27 hous.

[KayXo]

It is normal to take once a day. The half life is 27 hous.

The half-life is around 13-20 hours for oral estradiol, according to studies and monographs.

[ClaireXO]

The half-life is around 13-20 hours for oral estradiol, according to studies and monographs.

If the half life is 13-20 hours. I take it everyday at 7:05am. Does this mean once day is effective? Even if the half life is possibly 13-20hrs. I don't know how pills work generally. I am assume hormones stay in your system?

[Dani]

If the half life is 13-20 hours. I take it everyday at 7:05am. Does this mean once day is effective? Even if the half life is possibly 13-20hrs. I don't know how pills work generally. I am assume hormones stay in your system?

Any drugs half-life means that after that many hours has past from taking the drug , 50% of the drug is still in our bodies. In another subsequent half-life 50% of that is now remaining or now the drug blood level is down to 25% of the initial dose and so on it goes. Many clinicians feel that after 5 half-lives the drug is almost completely gone from the blood system or at least it is so low as to be no longer effective. All drugs are eliminated from the body by several methods, your kidneys and liver being the most common. The only time a drug will stay in your blood system is when the kidneys or liver are not working properly or if the drug has such an outrageously long half-life, that it is never eliminated from the body.

The 13-20 hours is for oral Estradiol. Other routes have some what different half-lives. 

[KayXo]

Some seem to do fine on just taking oral estradiol once daily. If you feel unwell, let your doctor know.

[epvanbeveren]

I am now... hmm... 9 months probably (?) on injections. I was scared as heck from needles and it took me close to 6 months to get used to self injecting and now I am totally okay with it, actually looking forward to my next Tuesday 6pm injection.

The reasons I switched:

liver, health ?
boobs, bigger ?
only once a week vs daily
cycle instead of steady (?)

Of course I have no proof of any of my reasons is true, but I think so, by looking at friends who inject after switching from oral.