Quote "We have data dating back to the 1960's and there have been studies disseminating everything so far gathered. IMHO, the data is sufficient to already draw certain somewhat solid conclusions like for instance, that breast cancer risk barely rises in this population (less than 20 reported since 1968) despite being prescribed for, at least 2-3 decades, very high doses of E (more often that not, non bio-identical) and sometimes progestogens like medroxyprogesterone acetate, 17-alpha hydroxyprogesterone caproate and cyproterone acetate. We also know that non bio-identical E increases the risk of DVT far more than bio-identical E in this population, similar to cismen and ciswomen. Prolactinoma is extremely rare (8 reported), as is prostate cancer (7 cases). Meningioma (10 cases) only seen with cyproterone acetate use, except one case and that is quite rare too."
Interesting comment and such wonderful technical medical terms. However, we need to employ stastics and very specific description of the population. The stastical data, population size, the time frame and the data gatheting methodology etc. is totally inadequate, at this time, to provide any scientific conclusion. It will take another generation or more for a definitive scientific conclusion as to the long term effects of E on TGs. We cannot use the HRT studies on cis females and draw any reliable scientific conclusions as we are anatomically very different. It will be very interesting a read, for all of us, when this data is sufficient.
As a personal view from very limited data and some understanding of the medical aspects of HRT, from Dr Bushong, who has 35 plus years of treating tgs, I would say that our lives are not shortened and hopefully lengthened. And maybe HRT on tgs is a mini fountain of youth.
