I have been using Suprefact (GNRH Agonist) Nasal Spray for about a year and a half now and it handled my T very effectively. Yes, I do have my ups and downs but nothing that I worry about.
As per your concerns, a combo of Estrogen and GNRH agonist could sometimes trigger this effect to some people. If you have not been on HRT for a long time, you will notice that transitioning happens both emotionally and physically. I would suggest talking to your medical professional if your anxiety gets out of hand.
Take care.