Just started on progynova.

[Skatarz]

I just started on  progynova  but noticed on the second day some twinges in my leg which are very slightly painful at last only 5 seconds which happened about 5 to 6 times. A bit dizzy, and tiredness. I think my dose might be a bit high so I broke the pill into 2 so  I just take half of my dose. I need some guidance and hope it's not to bad long term.


              <Dosage edits made by moderator>

[Bols]

Go see your doctor/endocrinologist. Maybe a quick visit to the GP clinic is a good first step. Your medical practitioner should be managing your hormone regime with blood work results. [emoji179]

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[Laurie]

  Hi Skatarz,

   I'm Laurie, the wandering waif of Susan's Place. I am also a moderator for Susan's Place. I would like to welcome you to our support site. I have to put on my moderator hat for a moment here and let you know that we do not allow the posting of dosages here as that could enable someone to self medicate. I have edited your post as required.
  Being new here. I will provide you with helpful links to our Terms of Service and User Agreement along with other useful information.  Come on in and take a good look around.  Perhaps I can even get you to hop on over to the Introductions Thread and  create a post to tell us a little bit more about yourself so we can get to know you a little better and greet you properly. I'll add some links and information below that can help you get more out of our site. Please take time to become familiar with them especially the RED one as we are always getting questions that are answered there.
 
Laurie
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Laurie@susans.org

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[Skatarz]

  Hi Skatarz,

   I'm Laurie, the wandering waif of Susan's Place. I am also a moderator for Susan's Place. I would like to welcome you to our support site. I have to put on my moderator hat for a moment here and let you know that we do not allow the posting of dosages here as that could enable someone to self medicate. I have edited your post as required.
  Being new here. I will provide you with helpful links to our Terms of Service and User Agreement along with other useful information.  Come on in and take a good look around.  Perhaps I can even get you to hop on over to the Introductions Thread and  create a post to tell us a little bit more about yourself so we can get to know you a little better and greet you properly. I'll add some links and information below that can help you get more out of our site. Please take time to become familiar with them especially the RED one as we are always getting questions that are answered there.
 
Laurie
Global Moderator
Laurie@susans.org

Things that you should read

Site Terms of Service & Rules to Live By	Standard Terms & Definitions	Post Ranks (including when you can upload an avatar)	Cautionary Note
Reputation rules	News posting & quoting guidelines	Photo, avatars, & signature images policy	Membership Agreement

I have basic concerns. I need advice on what I wrote. Hope you can get back to me please.

[Laurie]

Hello Skatarz,

  I am sorry you have had those pains you spoke of. I have no medical training like most of our members. The questions and concerns you have should be answered by your doctor. I do hope you have a doctor and are not self medicating. Taking hrt medication and other drugs can be dangerous, even life threatening. The pains you describe could be something serious or it may not. Are you willing to bet your life on it? Please ask a physician for sound advice, tests, and treatment.

  FYI giving unqualified medical advice's also against our Terms of Service.

Laurie
Global moderator
Laurie@Susan's.org

I have basic concerns. I need advice on what I wrote. Hope you can get back to me please.

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[Kirsteneklund7]

Hi Skatarz,
As you probably know Progynova is a highly effective estrogen medication it gets results but is not a bioidentical estrogen. All I am saying is that if you are worried about blood clots from HRT consider bioidentical estradiol gel. It is low risk with regards to blood clots. Also contrary to heresay it is as effective as injections when monitored via blood tests. Blood estradiol levels can be maintained as high or as low as required. Sandrena gel is readily available as a prescription. Other gels also.
Good luck with everything,
Kirsten.

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[Ellement_of_Freedom]

You need to see a doctor about this. Taking progynova does increase one's risk of thrombosis which can be extremely dangerous.

[Skatarz]

One of my childhood friends studied medicine in Russia and is qualified doctor though he no longer is interested in the medical field. I told him about this and he said to monitor and report if any symptoms.

[Dani]

I need to clarify a few statements here.

The generic name for Progynova is estradiol valerate. This is a pro-drug to estradiol. It is not active in the body until the valerate portion is cleaved off and releases active estradiol. It is considered to be bio-identical, but not until the valerate portion is gone.

This medication is usually given by intramuscular injection, with 100% bio-availability. Since the valerate portion is not removed all at once, it acts like a timed release medication, with a half-life of 4 to 5 days. The oral form of this drug is only 3  to 5 % bio-available and has a half-life of 12 to 20 hours. Because of the limited bio-availability, very few people, in the US, take oral estradiol valerate, preferring to take micronized estradiol, either oral or sublingual.

From the original post, she reported two unpleasant side effects. The dizziness and leg cramps are not normal side effects associated with estradiol valerate. Dizziness is associated with other hormonal disturbances, such as in menopause. The leg cramps would most likely be caused by something else.

While we try to be helpful and supportive here at Susan's Place, we cannot diagnosis your specific situation. We can point you in the right direction. As others have said, you need to have a talk with the doctor who prescribed you the Progynova. There are other choices for HRT.

 

[SadieBlake]

Skararz, welcome and it's quite likely what you're experiencing is simply psychosomatic symptoms. Most of us wait a long time getting to the point of starting HRT and the anticipation will create some strong emotional feelings for most of us!

That said, pain in the legs could be what we fear most, a symptom of venous thrombosis which *can* be caused by HRT. This can be life threatening and if you're not under a doctor's care you need to be, principally because of just this risk.

Lookup the symptoms of VT and also you should know that being overweight or inactive both put you at higher risk of VT.

[herekitten]

Skatarz, I hope you are able to find the source of the twinges in your legs. I hope its not the estrogen. I am sure everyone would like to know what it was after you consult with your doctor. Keeping my fingers crossed for you that it is only a muscle spasm or something simple.

[Skatarz]

The following days on 25th to 27th today no twinges at all. I heard estrofem might have less severe side effects on lower doses so I'm thinking of getting of progynova for good. I told my doctor friend I'm doing this only temporary.  I'm switching to transfemme bovine ovary when I have saved enough and from there I won't need any harmful drugs for life.



One of the best things about using our male to female hormone system is you are not using a drug, you are not putting a hormone into your body. Instead, you are creating a forced feminization scenario whereby your body converts from M to F hormones. This is much better than using synthetic hormones or hormones made from pregnant horse urine which is very unnatural to the body.


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[Skatarz]

Estrofem is micronized estradiol.

[Skatarz]

The generic name for Progynova is estradiol valerate. This is a pro-drug to estradiol. It is not active in the body until the valerate portion is cleaved off and releases active estradiol. It is considered to be bio-identical, but not until the valerate portion is gone.

http://www.fertilityfriends.co.uk/forum/index.php?topic=191117.0

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Re: Difference between Estrofem(Hemihydrate) and Progynova (valerate)
http://www.fertilityfriends.co.uk/forum/index.php?topic=191117.0« Reply #1 on: 15/04/09, 18:10 »
Hi Joyce,

In terms of active ingredient then there is no difference between them as both contain estradiol, which is the hormone responsible for thickening the lining. The Estrofem is the 'pure' drug and the Progynova is a compound containing the pure drug in combination with the valerate salt. You should be able to swap between them as needed but be aware that the doses may be slightly different so you'd need to speak to your clinic and see what they advise for an equivalent dose.

Hope this helps
Maz x


I'm switching from Progynova to Estrofem as estrofem is pure estradiol without the valerate. It is safer?

[Skatarz]

I need to clarify a few statements here.

The generic name for Progynova is estradiol valerate. This is a pro-drug to estradiol. It is not active in the body until the valerate portion is cleaved off and releases active estradiol. It is considered to be bio-identical, but not until the valerate portion is gone.

This medication is usually given by intramuscular injection, with 100% bio-availability. Since the valerate portion is not removed all at once, it acts like a timed release medication, with a half-life of 4 to 5 days. The oral form of this drug is only 3  to 5 % bio-available and has a half-life of 12 to 20 hours. Because of the limited bio-availability, very few people, in the US, take oral estradiol valerate, preferring to take micronized estradiol, either oral or sublingual.

From the original post, she reported two unpleasant side effects. The dizziness and leg cramps are not normal side effects associated with estradiol valerate. Dizziness is associated with other hormonal disturbances, such as in menopause. The leg cramps would most likely be caused by something else.

While we try to be helpful and supportive here at Susan's Place, we cannot diagnosis your specific situation. We can point you in the right direction. As others have said, you need to have a talk with the doctor who prescribed you the Progynova. There are other choices for HRT.

Is estrofem micronized estradiol? Does it have a half life?

[Dani]

Is estrofem micronized estradiol? Does it have a half life?

Estrofem is actually estradiol hemihydrate. It is not micronized estradiol.

The main drug is still estradiol, but the hemihydrate form is not meant for sublingual administration. The micronized form of estradiol can be taken both oral and sublingual. Estrofem is oral only. Because of this, Estrofem goes to the liver for the first pass before it travels to the rest of the body. Blood levels are not quite as high as with sublingual micronized estradiol, but the half life is much longer, about 18 hours, making once a day dosing acceptable. 

[Skatarz]

Estrofem is actually estradiol hemihydrate. It is not micronized estradiol.

The main drug is still estradiol, but the hemihydrate form is not meant for sublingual administration. The micronized form of estradiol can be taken both oral and sublingual. Estrofem is oral only. Because of this, Estrofem goes to the liver for the first pass before it travels to the rest of the body. Blood levels are not quite as high as with sublingual micronized estradiol, but the half life is much longer, about 18 hours, making once a day dosing acceptable.

so would estrofem once a day be ok?

[Cindy]

Please go and see a medical doctor.

Seeking Medical advice on this Forum to self medicate is not allowed.


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Cindy

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