Transition isn't the right answer for everyone, but for those of us where it is - I don't see the decision as what to sacrifice. If someone has a problem with my medical condition and decision, what has been sacrificed? Are they the ones dealing with prescriptions, frequent blood tests, learning a new language, mannerisms, potential surgery and recovery, changing a bunch of legal documents and on and on. Exactly how does this inconvenience them? If a "friend" is uncomfortable with who I really am, well now I know I didn't sacrifice a friend and they were just an acquaintance. If a family member reacts negatively, then I'll know their love was conditional all along and they value my existence less than their perceived social status (the chilling "what will the neighbors think" argument - think about what that really means). In either case I don't think anything has been sacrificed. Sometimes the truth hurts but it's worth it.
You should make the best decision for your future. You own it.