Most of us don't look anything like runway models, so practical fashion is all about looking good with what we have. Or, for many TGs, what we don't have, like hips and butts.
GGs typically deal with height, weight, body shape, and skin tone. Sometimes someone's favorite color will make them look sickly.
Mixing patterned prints is likely to look to busy or confused, but some clever people have the gift that allows them to break just about any "rule."