My doctor has over 15 years experience working with transgender patients, but I expect no two are exactly alike. She started me on estradiol only, and she did not order any baseline hormone tests. After four months my testosterone was still over 600, so she added spironolactone. Four months later my T was down to 100, but my estrogen levels were only in the mid-50's. A few checkups later I was successful in getting my estradiol doubled, and my estrogen levels went up to 240, while my T become unmeasurably low -- and I was happier than ever.
By the way... enjoy the ride Joanne and Chris39!