I don't know the answer but I learned that my father's side of the family has a lot of depression problems. I was concerned with meds changing me into a "veg" or something. I've since learned that the right ones just make life normal. I'm not euphoric. I'm not vegged out I'm just having a normal which feels a lot better then chronic depression. I guess I could add anxiety issues but for me thats more event driven and does not appear to be genetic. But again there was a great(er) concern about meds and I have again learned that the right drugs taken in the right dose just get me to a functional normal. Ok, what I take is a bit sedating but 100x better then a panic attack. I would put in a pitch for therapy but I think most of us here are ok seeing a therapist.
HRT seems to be helpful in this as well but that can often be a second issue in addition to depression. At least that is my thinking. Either way good luck! Don't let depression slide its an awful way to live.