I went with no blockers and E only, to keep from taking anything else if I could help it. Got to the point where I felt that E is relatively low risk. Started in patches, but a month of rashes and a patch or two that rolled up on me, and I switched over to injectable. I'm just too much of an airhead to remember taking pills everyday. Everyone is of course unique, but in my case, I got what I wanted, T levels bottomed out on E only (so far). I had really low T levels to begin with. I thought about orchi up front too, but E felt like the more gradual approach to find the right balance for myself. Plus, I'm squeamish about surgery. I've found my dysphoria so much easier to manage now.