I've been on estradiol valerate now for just over 2 months. For me the switch to estradiol valerate was due to pills not being effective. I was also on patches but got tired of sticking 3 on at a time to get my levels close to where they should be. Injections have been pretty awesome so far, and I found they're not as bad as I thought they'd be to give to myself. I've even had to lower my dosage once due to my estradiol being too high. The biggest pain is that it takes forever for it to draw into the syringe.
I feel like my skin has gotten a bit softer and breast growth seems to be picking up again, although it could just be that I'm finally noticing after being on hormones for almost a year and a half total. I've also noticed many more people calling me she or ma'am, but that could also be due to getting my hair colored and getting better at hiding beard shadow.
To be completely honest, if they worked for me, I'd rather be on pills, just due to them being much less of a hassle and easier to take. Injections are so much better than being on patches however. Also, because I give myself injections on Saturday, I now call it "Staburday".
Diffi