Highest level variation, and thus potential non liver related estrogen side-effects are
related to injection. That's why people often supplement with pills at the end of their cycle.
With injections you have to make sure you don't hit a vein and keep your needles new.
Patches, very safe, the new small ones much better than larger ones, but its hard to
get a GG physiological level unless you plaster yourself with them (one patch rellieves
menopausal symptoms, but that's far from normal GG level. They are also very expensive
if you want to get a decent level of estrogen into you.
Pills, dirt cheap, convenient, non painful and
quite safe if you use the right pills.
If you use estradiol or estradiol valerate and
NOT ethnilestradiol, a conjugated estrogen or premarin.
BTW, don't know why people keep talking about the liver load of estrogen,
its minor for bio identical estrogens (estradiol), much
smaller than that caused by a tylenol tablet.
Its the clotting promoting byproducts of liver removing estrogen
from the blood that is the issue and its only a big issue really with ethinilestradiol,
conjugated estrogens, premarin or very very high serum levels (pregnancy levels) of
estradiol (which is not easy to do with pill form estradiol (much pills per day)).
This is supported by studies on the DVT effect of ethinilestradiol and conjugated estrogens
versus using bio identicals.
