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Which Progesterone ?

Started by Laura Eva B, September 29, 2008, 08:18:15 PM

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Laura Eva B

I'm seeing my NHS (UK) endocrinologist tomorrow afternoon for my regular "six monthly" .

My post-op HRT regime has included Duphaston (Dydrogesterone) as my progesterone, but this drug has now been discontinued as far as UK distribution to UK pharmacies, (though Inhouse Drugstore still seem to stock it).

What I want urgent advice on is what would be a suitable alternative, as I guess my endo will be OK to go with "my choice" given no contra-indications which she is aware of, and she doesn't really know the differences between micronized progesterone and synthetic progestins in TS HRT useage (but then neither do I !).

Should I go for Provera or Microgest/ Prometrium or what else ?

What are other women taking ?

I'll be leaving the clinic with a 3 month prescription and I'm unsure
what should be replacing Duphaston (indeed if Duphaston was ever the
best choice for me as I guess its a progestin too ?).

Any help or advice very much appreciated.

Laura


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Flan Princess

Supposedly micronized progesterone is safer and more effective, however the way the body processes it vary greatly. I myself have taken Provera and was happy with the results.
If NHS is willing to go the extra mile (kilometre?) and support you with micronized progesterone, (especially the dosing so that everything is ok) then I would say go for it.
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sresha

I have found two progestins that work fabulously for me, even better than micronized progesterone: Chlormadinone Acetate and Dienogest. Either one is fine. I know this might seems counterintuitive because we're told not to use synthetic progestins. Well this is true only in so far as the ones in the popular contraceptives, like levonorgestrel, norethindrone, norgestrel etc. Those are actually derivatives of 19-nor-testosterone, so seriously do not even think about taking these if you're TS (pre or post). They WILL have some androgenic effects long term. I personally do not like Provera either.

Now with chlormadinone and dienogest, they are actually derivatives of natural progesterone, even though they are technically "synthetic" because their molecular structure is not identical. But they are the closest thing you can get to natural progesterone and they have the same anti-androgenic effects, but without the terrible dizziness, drunk feeling that micronized progesterone gives many people. Unfortunately, these are not available in the US, but since you're in the UK you should not have trouble finding one or the other.
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