Some AAs with little/no neurological effect?

[Inanna]

According to several studies I've read and doctors I've talked to, certain anti-androgens that only work by affecting T's ability to bind to its receptor site have a weak neurological effect (I believe this includes flutamide/bicalutamide) .  I'm curious if this is because these cannot go past the blood-brain barrier.

The reason I'm interested is because I've had fairly low energy, slept longer, & been less active since going on Spiro.  In the past, I've tried only taking E with no Spiro, and my energy & activity levels increased pretty significantly.  Of course, though, that's not a long-term solution.

[Hannah]

Are you taking only Spironolactone? For how long?

I don't know about spiros neurological effect. Spironolactone is such a neat medicine it could be any range of things causing your symptoms, all of the side effects I'm sure youve read about. I don't know for sure if one would want to take high doses of it without some other sex hormone at the same time, a lack of sex hormone would certainly cause the symptoms you mentioned. I stepped the spiro up slowly over the space of a few months, and with every increase of dosage I felt what your'e describing but it went away, and now that it's at full strength combined with estradiol I feel fine.

You can hurt yourself playing chemistry set with your body sweety, be careful. It sounds like your doctor is about as clueless as mine, so I might suggest educating yourself and knowing what you want and *cough* roughly how much, and then having the doctor provide labs and adjustments from there.