I have taken Premarin and the on-off effects were very severe. I was crying all the time when on meds, and mental things really affected me badly. When I went off Premarin I had hot flashes but generally stopped the moodiness and crying jags.
Fast forward about 10 years and I restarted again, but this time on Progynova. NO mood swings and NO crying at Bambi movies either.
I sometimes like to stop taking them cold turkey and I get swelling and a lot more tenderness in the breasts and they get hard and very perky! That lasts for about three weeks and then I re-start the Progynova all over again.
Back again on Progynova for 8 to 12 months and I just continued with breast growth, hips fat and my butt has gone rounder and smooth. Everything seems to stay or hold until I restart, but that might be from using estrogen for quite a few years now and I bet if I totally stopped forever, things would not change much or at all now.
I have never lost breast size during those "off-times", but sensitivity changes radically deep inside the breast tissue and when they bounce they cause small pains {that I like}. Cannot say that I get depressed or weak, but that's because there's no laws in medicine - only results and they vary with every person. Originally I was prescribed Premarin to cure my migraines, and they were cured in about the first week although I was kept on them for 6 months and developed a solid B chest.
Now at considerable years later, I am all the way out to a full C and just enjoy what I have.
