Is this Premarin?

[KayXo]

I don't think it is overstated as it contains a significant amount of equine estrogens as well that the liver takes time to metabolize, so stay longer in the body and more significantly stimulate clotting factors. When you have an equally EFFECTIVE estrogen, called estradiol that is safer for and produced naturally by the human body, why take something that is higher risk? Estrone is also weaker than estradiol, about 12 times, from what I read and its conversion to estradiol is quite limited and seems to be to a much lesser degree than the other way around. I suspect that most of the feminization effect one gets from Premarin is from its horse (equine) estrogens.

Two equally effective options with one option being safer? Which would you choose? I think it's pretty obvious, don't you think??

[ImagineKate]

The horse estrogen thing is really overstated. The primary estrogen in Premarin is Estrone, which your body converts to Estradiol. It is endongeous to the female body by the way and of course, allows your own body to make your own estrogen (via conversion). The real concerns should be it's effect on the liver as mentioned and that it's got a bit of a higher risk for clotting. As for results, I have to say my results have been excellent and I'm primarily switching off it to give my liver a break, as I take other pills as well. The girls are certainly quite big from them xD

I thought that estradiol is metabolized to estrone not the other way around.

[KayXo]

I thought that estradiol is metabolized to estrone not the other way around.

It goes both ways. But, from what I gather, the conversion estradiol to estrone is more active. Progesterone (and perhaps all progestogens?) apparently seems to increase conversion of estradiol to estrone.

[Yukihime]

I don't think it is overstated as it contains a significant amount of equine estrogens as well that the liver takes time to metabolize, so stay longer in the body and more significantly stimulate clotting factors. When you have an equally EFFECTIVE estrogen, called estradiol that is safer for and produced naturally by the human body, why take something that is higher risk? Estrone is also weaker than estradiol, about 12 times, from what I read and its conversion to estradiol is quite limited and seems to be to a much lesser degree than the other way around. I suspect that most of the feminization effect one gets from Premarin is from its horse (equine) estrogens.

Two equally effective options with one option being safer? Which would you choose? I think it's pretty obvious, don't you think??

You're very, very incorrect regarding the feminization effect being from Equine. First of all, Equilin  and it's companion equilenin only comprise 15-25% of Premarin. There is no way you'd get the majority of feminization from those as they're discarded from the body after taking Estrone in. It's rate of conversion to Estradiol is quite good honestly as my Estradiol levels have been quite nice and my feminization has been coming along well.
   

I thought that estradiol is metabolized to estrone not the other way around.

No, otherwise Premarin would not be effective. Estrone sulfate is absorbed into the blood then converted to Estradiol.

I just want to say that there's a lot of misinformation about Premarin floating around here and preconceptions. If you haven't taken a medication, no matter how much you've researched, it's best to refrain from talking about it. Otherwise you'll give people who do take it bad info among other things.

[CollieLass]

I just want to say that there's a lot of misinformation about Premarin floating around here and preconceptions. If you haven't taken a medication, no matter how much you've researched, it's best to refrain from talking about it. Otherwise you'll give people who do take it bad info among other things.

Thankyou for reminding that there is no 'best way'.........there are indeed 'many ways'.

I`ve taken Premarin for over 33 years; it has served me very well indeed through a successful early transition into adulthood, and now in old middle-age, and I haven`t suffered deleterious effects.......The "horse-pee" derision wears a little thin at times to be honest, please remember that there are several generations of 'us' for whom Premarin based HRT has been our life-saving salvation.

Kind regards,
Deb. 

[KayXo]

First of all, Equilin  and it's companion equilenin only comprise 15-25% of Premarin. There is no way you'd get the majority of feminization from those as they're discarded from the body after taking Estrone in. It's rate of conversion to Estradiol is quite good honestly as my Estradiol levels have been quite nice and my feminization has been coming along well.

From CLIMACTERIC 2005;8(Suppl 1):3–63

Premarin consists of

Estrone 49.1 %
Equilin 22.8 %
17a-dihydroequilin 13.5 %
17b-dihydroequilin 1.5 %
Equilenin 2.8%
17a-dihydroequilenin 1.6 %
17b-dihydroequilenin 0.7 %

Thus, overall equine estrogens comprise 42.9% while the rest is MOSTLY estrone. Estrone is quite weak and its rate of conversion to estradiol low.

otherwise Premarin would not be effective. Estrone sulfate is absorbed into the blood then converted to Estradiol.

Equine estrogens stay A LONG TIME in the body as they harder to metabolize by the liver whereas estrone and estradiol have a much shorter half-life. Premarin is effective thanks, mostly, to equine estrogens. Estrone sulfate is first converted to estrone then later to estradiol.
   

[V M]

Okay friends

I believe that Amy has gotten her answer, and that this topic has run it's course

For future reference let's all try to remember rule 8 of the ToS

8. The discussion of hormone replacement therapy(HRT) and it's medications are permitted, with the following limitations:
A. You may not advocate for or against a specific medication or combinations of medication for personal gain. This is strictly prohibited.
B. You may not discuss the means to acquire HRT medications without a prescription. The discussion of self medication without a doctors supervision is prohibited.
C. The discussion of recommended or actual dosages is strongly discouraged to prevent information obtained on this site from being used to self medicate.
We can not in good conscience condone the self administering of these medications. Not only may self medication be illegal, but HRT medications can cause serious health problems, and many have the potential for life-threatening side effects that can only be detected and prevented with proper medical supervision.

Thank you

V M