Engineered Rabbit Penises Raise Human Hopes

[Cindy]

I read this as an Aussie scientist and thought.
Great. Here we are a country over run by rabbits, terrible destructive vermin. Now some clown has found a way make more randy rabbits, what a break through. Next time they'll make Cane toads with wings.

Aplogies this is a bit of an Aussie joke/comment.

Realistically I thing organ culture techniques are going through an exposion at the moment. Hang out for some very exciting news.

Hugs
Cindy. Now where's that darn rawwbit

[Silver]

Anyone here play Bioshock?

[Seshatneferw]

... hubby has looked at this and gone "hrrrmpfh!.. this means you could, in theory, when the technology is ready, choose your own size! that's not entirely fair... I didn't get to choose... " ^^

Then again, once the technology is ready he will also be able to choose his own size, he'll just have to go through a smaller-scale version of the surgery you'll have, with somewhat smaller but still significant risks. Considering the amount of penis-enlargement advertising we all get already, his surgery is even likely to become available sooner than yours...

But back to the main topic, this sounds really promising. Yay!

  Nfr

[Allamakee]

Okay, the actual article is finally online.  It is titled "Bioengineered corporal tissue for structural and functional restoration of the penis."

Sadly, to view it will cost $10.  But here is the abstract:

Various reconstructive procedures have been attempted to restore a cosmetically acceptable phallus that would allow normal reproductive, sexual, and urinary function in patients requiring penile reconstruction. However, these procedures are limited by a shortage of native penile tissue. We previously demonstrated that a short segment of the penile corporal body can be replaced using naturally derived collagen matrices with autologous cells. In the current study, we examined the feasibility of engineering the entire pendular penile corporal bodies in a rabbit model. Neocorpora were engineered from cavernosal collagen matrices seeded with autologous cells using a multistep static/dynamic procedure, and these were implanted to replace the excised corpora. The bioengineered corpora demonstrated structural and functional parameters similar to native tissue and male rabbits receiving the bilateral implants were able to successfully impregnate females. This study demonstrates that neocorpora can be engineered for total pendular penile corporal body replacement. This technology has considerable potential for patients requiring penile reconstruction.

http://www.pnas.org/content/early/2009/11/12/0909367106.abstract

I guess we'll just have to wait for the printed journal to show up in the library.

[metal angel]

you could skip some of the engineering if you got a donor organ to strip the cells away from and re-seed with patient's cells... not sure how that would go down though, too many people needing harts and livers right now to risk anything that may reduce donor organ numbers by creeping out a few people.

[Jesslee]

Its amazing news for anyone with flesh bodies. This science could be applied to anything else assuming one had a different approach for vaginal stuff...


But seriously... I agree.

It already has been applied to "vaginal stuff" on humans. I posted on this topic over a year ago but it got a few laughs (rabit penis jokes) and very little attention.

I would love to know why none of the SRS doctors have spoken about this New technology, it seems like it would make SRS much easier with better outcomes.


Maybe we should begin a campaign of contacting doctors such as Bowers, Brassard, Metlzer, etc.. and ask them why they are not investigating the possibilities using this technique.  What do you think?



here is some info:

"http://news.softpedia.com/newsPDF/Breakthrough-Lab-Grown-Vaginas-59903.pdf"

"http://www.abc.net.au/science/articles/2007/05/31/1938525.htm?site=science&topic=health"



"Current methods to reconstruct a
vagina are based on grafted skin or intestinal tissue, but this surgery is highly invasive,
lengthy and painful, requiring a long time to grow a normal vagina mucosal wall. But now,
Marchese has managed to build brand new vaginas in two MRKHS women, using their own
cells to get vaginal tissue in the lab for the first time.


The mucosal tissue covers the
inside of the vagina, the mouth, digestive and breathing tracts. "What we do is to take a little
biopsy of 0.5 centimetres from the place the vagina should be," said Marchese.Using an
enzyme, the researchers broke down the tissue and cultivated stem cells (immature type) to
grow new, mucosal tissue on their own. "It takes about 15 days to get a thick enough layer
to transplant into the patients," said Marchese. Marchese investigated the use of stem cells
to build sheets of skin in vitro to get skin grafts for burn victims at Harvard Medical School."

[Flan]

wiki updated (thanks Jesslee)
the full paper on this research can be freely viewed here
http://humrep.oxfordjournals.org/cgi/content/abstract/22/7/2025

the reason it isn't being done for trans women, is the need for a full thickness sample to cultivate the stem cells with, once that's figured out, in persons lacking the cells, by using other cells, then it can be trialed on trans peeps (currently it's for persons born intersex)

[metal angel]

so transwomen don't have the right source tuissue to grow the graft from?

[Flan]

so transwomen don't have the right source tuissue to grow the graft from?

The patient was subjected to a 1 cm² full-thickness mucosal biopsy from the vaginal vestibule.

no, not using the linked technique as is