It's about as funny as most of the stuff he does, which is marginally so-so at best. The absolute best comedy can't even be shown on network TV. They have to put people like Lisa Lampenelli, Kathy Griffin, and Neil Hamburger on cable, and even then it's heavily edited - except for Hamburger, they won't even show that stuff on cable.
He is a stand-up comedian, not a political figure, or a political group. He has no power, only jokes.
And, by virtue of accepting the appointment she knew she was becoming a public figure.* And I'm sure she knows it goes with the territory. What's more, having heard nothing from her (the correct response) I have to assume that like most such things in life, people with real and major accomplishments pay little heed to such things. Its tends to flake off people who have tended to do little or nothing in their lives. Because to such people, image is all they have. People with accomplishments have no need to worry because the accomplishments stand for themselves, and at the end of the day she is still has her government job, she still has degrees in physics, engineering and business administration, along with an extensive flight background, and she is still an expert in weapons systems. Considering what kind of work she does, a joke is just a joke, killing people is her life work, as her last job was Deputy Director in Advanced Technology Development at Raytheon Missile Systems - which are not exactly delivering lollipops to good little kids.
I'm sure she knows the difference. And, anyone who has ever worked with the 'more bang for the buck' crew knows, their sense of humor is very, very black. They tell dead baby jokes to amuse each other and frequently refer to their successful targets as 'crispy critters.'
* She ran for Congress in ever-liberal Arizona in 2004, so none of this is new for her.