So far, the reactions have gone as follows ...
1. Therapists, doctors, other medical professionals ... no problem. My therapist, who is a senior consultant, has since said he would support me through transition and, if I wanted it, SRS. My family GP was amazingly mellow and again, supportive.
2. Friends ... I've so far only spoken to five in real detail: three women (one transgendered) and two guys. ALL the women have been wonderful, happy for me that I am finding a path to my true self, absolutely there for me, looking forward to the day we can go shopping together! Of the guys, one has been amazingly positive, the other was very personally supportive but cautious/sceptical about (a) the degree to which I could ever pass and (b) the degree to which people who had known me well as a guy would ever be able to adjust to a new female identity. i should stress that I had specifically asked him to be as brutally honest as possible and that there was no hostility/disrespect intended or taken.
3. My wife ... I came out a week ago, in the context of a two-hour session with the family therapist (I wanted this to happen in a secure, moderated environment, for both our sakes). She was remarkably calm, not angry, nor entirely surprised, said she still loved me ... but then asked me to give her a few days, undisturbed to think about it. She has just suggested we go out to dinner tonight, so I guess she's going to tell me what she thinks.
All-in-all, I have to say that it's been an amazing experience for me so far. And I don't know if it's just coincidence, but I am now sleeping better than I have done in ages.
But to address (finally) your specific point about scripts, I have to say that I thought VERY carefully about how to approach this, particularly with my wife. I let the family therapist manage the session very carefully so that everyone's needs, and rights to express themselves were addressed, and I am incredibly glad I did it that way. Obviously, this isn't an option open to everyone, but I really recommend it if possible.
With my friends, I've relied on a lot of talk, just keeping conversations going, answering their inevitable questions as honestly as possible ... being aware of the weight I am placing on them and my responsibility to honour their reactions.
I think, BTW, this is terribly important. We expect other people to be tolerant and understanding of us. But we have a duty, too, to be tolerant and understanding of them. We've all been thinking about our situation for years, sometimes decades. But it's a helluva shock for them when it comes out of the blue. It's not fair to expect others to be cool with it in an instant. They need to process, just as we have done. And they have a right to express their fears, doubts, etc, even if what they say makes us uncomfortable. Because we've sure as hell made them feel uncomfortable, after all ...