In a word: YES. Absolutely. If you have any sense of pride about your tits at this point, and for some reason want them to remain pretty and perky, just say no to binding. I've been binding consistently for about 3 1/2 years now, and I refer now to the chesticles as "pancakes". Honestly, that's what they resemble at this point. The breast tissue has broken down to such an extent that they lay fairly flat against the top of my stomach, and the only thing keeping me from not binding is the fact that my pecs cause the remaining breast tissue to protrude slightly.
And by the way, it doesn't take long for this to happen. I noticed a difference in tissue mass after about 6 months.
SD