I currently inject. However, I used gel for a short period, liked it, but it is very expensive. Putting it on is a very sensuous act. I used patches for years. Less expensive, but I am prone to eczema, sort of a minor red rash. The patches also leave a slightly sticky residue that is hard to get off. I never felt quite as smooth while using them compared to gel or the injections. It wasn't terrible though. Some girls seem to have a problem during the summer, while outdoors, and having them fall off from sweating. I work inside and that was never a problem for me. It is my understanding that all methods of estrogen intake work just as well, although some users swear about the efficacy of one over another. I believe that it is just cost and ease of administration that makes a difference. Good luck.