I've been on HRT for two months and have noticed breasts buds and sometimes my breasts seem very full, other times they feel flat as a pancake, except for the mile high nipples. I was just wondering what causes the breasts to change size from full to flat over the course of a day? Is that an ok thing? Is it something I should share with my doctor? Could it be a sign that my HRT dosage is not keeping enough levels of estrogen and anti-androgens in my system as the day progresses: a sign that I need to spread out my dosages over the course of the day.

And I know that I'm not just imagining this because someties I can cup my breast in my hand and it fills the whole hand without any problem and other times my hand might as well be trying to cup a piece of paper. Like right now at 9 in the morning I can cup my breast without any problem. But by like noon maybe I'm guessing I won't be able to do it as easily, and by like 5 it will pry be impossible. 

water in the body, normal swelling that can happen while you sleep,kind of like puffy face, lol. I'm pretty sure its normal and it sounds as if you aren't using calipers or other scientific measuring devices to verify this, so it could just be a bit of perception mixed in as well that may make it seem more extreme than it actually is.

Gosh, I don't know. When I went on my hormone regimen, my breasts budded and became quite large and very sore/sensitive. I have never heard of them appearing and disappearing over the course of the day.