I do have other autoimmune anomalies, and have been told this may get worse on estrogen, so perhaps this is a direction to look in, just in case. My immune system was in any case borked in early childhood by something mysterious (it was the 60's, and Israeli doctors were not yet at the top of their game) caught from dog poo. I catch any virus that's going around, and take longer to get over it. At least I have my humour(s).