http://www.thewileyprotocol.com/about-the-wiley-protocolr/about-ts-wiley.html

Is anyone familiar with this bio-identical protocal? I am considering seeing a MtF HRT doc (Courtney Ridley) in the Dallas area for my HRT needs and this is one of the things I hear she recommends.  Thanks

The trend towards bio-identical hormones isn't very new, although the so called "wiley protocol" is, at least to me. As far as I understand going through the site, "wiley protocol" is nothing more than a trademark for the promoter, Teresa S. Wiley. I wouldn't be surprised if that's the sole source of her income (peddling books to gullible physicians and consumers).

Any doctor can prescribe the same drugs and get the same results, which assumes a slow rate of absorption through skin resulting in "overdose." Yeah, like the body does nothing with the hormone, what, so, ever. In a nutshell it's cycling the dosage to mimic the monthly cycle (what they call "Rhythmic Living").

I have to wonder... I know HRT protocols vary widely from one doctor to the next, but shouldn't the medical community have a basic agreement  as to how hormones work, and how to best utilize them for our goals? Why would this woman be so differnet in her approach that few other Endos feel the same way? 

Quote from: DaniStarr on December 25, 2012, 09:47:41 AM
I have to wonder... I know HRT protocols vary widely from one doctor to the next, but shouldn't the medical community have a basic agreement  as to how hormones work, and how to best utilize them for our goals? Why would this woman be so differnet in her approach that few other Endos feel the same way? 

17-B-estradiol is the same whether it has been synthesized in a lab, or whether it has been purified from mares urine, or other organic source.

Bioidentical drugs, including those for TS/TG patients, have a different formulation and monitoring regime. The Food and Drug Administration of the USA as well as many medical associations -including the American Society of Endocrinologists- do not  recommend their use. If you are still determined to take bioidentical hormones, make sure are the ones that are FDA approved.

See the article below -  that I pulled out just for you    -

http://www.health.harvard.edu/newsletters/Harvard_Womens_Health_Watch/2011/September/bioidentical-hormones-help-or-hype

Hi Peky,

I wasn't referring to the type of hormones(Bio Identical vs synthetic) so much as the way they are taken. In her video, she goes into great detail about how certain hormones should be at certain levels during the month. She was basically saying the hormones should be administered as the female body produces them at various times of the month. She also stated that receptors will shut down based on certain times of the month. So basically she states that taking estradiol at the same dose for the the month is counter productive.

I'm no expert by any means. But with the exception of dosage and  adding progesterone to ones HRT regimen, it seems that the medical community don't have any huge difference of opinions among them. So I'm wondering if this lady is really smart or just full of it?

P.S.

Thanks of the link   

Quote from: DaniStarr on December 25, 2012, 08:17:53 PM
Hi Peky,

I wasn't referring to the type of hormones(Bio Identical vs synthetic) so much as the way they are taken. In her video, she goes into great detail about how certain hormones should be at certain levels during the month. She was basically saying the hormones should be administered as the female body produces them at various times of the month. She also stated that receptors will shut down based on certain times of the month. So basically she states that taking estradiol at the same dose for the the month is counter productive.

I'm no expert by any means. But with the exception of dosage and  adding progesterone to ones HRT regimen, it seems that the medical community don't have any huge difference of opinions among them. So I'm wondering if this lady is really smart or just full of it?

P.S.

Thanks of the link   

Her site does not have "the protocol" or it could not be opened. As far as her "peer reviewed" publications, the three listed paper have absolutely nothing to do with her claims or protocols. her peer reveiw publications deal with gene expression.

The rest of her publications are of little value, like in the internet in the non-peer-reviewed literature anybody can publish anything.

Do you have a link or a copy of the actual protocol? I will be glad to take a look and give you my opinion.

I once asked my Endo why he didn't cycle my HRT regime to mimic that of a female. His reply was somewhat obvious. He basically asked whether I wanted to fall pregnant. (Although I do, but quite impossible)

Thatis the reason a females hormone levels are all ver the place. They are preparing the ody for possible fertilisation of an egg. If it doesn't happen, the body is cleansed and the cycle starts all over again.

He also suggested, for the best results for my transition would be to implement the best consistent form of HRT delivery. He then hit me with an implant which has exceeded expectations due to effectiveness of delivery.

Hope yours goes the same way.

Huggs
Catherine

It seems there has been so little real research on HRT and even less when it comes to research for trans-HRT.  It's ridiculous that the medical community can't even decide if progesterone is needed in our HRT protocall or not.

Quote from: JessicaH on December 26, 2012, 11:52:23 AM
It seems there has been so little real research on HRT and even less when it comes to research for trans-HRT.  It's ridiculous that the medical community can't even decide if progesterone is needed in our HRT protocall or not.

Below quote is taken from the last version of WPATH guidelines

Progestins
With the exception of cyproterone, the inclusion of progestins in feminizing hormone therapy is
controversial (Oriel, 2000). Because progestins play a role in mammary development on a cellular
level, some clinicians believe that these agents are necessary for full breast development (Basson &Prior, 1998; Oriel, 2000). However, a clinical comparison of feminization regimens with and withoutprogestins found that the addition of progestins neither enhanced breast growth nor loweredserum levels of free testosterone (Meyer III et al., 1986). There are concerns regarding potentialadverse effects of progestins, including depression, weight gain, and lipid changes (Meyer III et al.,1986; Tangpricha et al., 2003). Progestins (especially medroxyprogesterone) are also suspected toincrease breast cancer risk and cardiovascular risk in women (Rossouw et al., 2002). Micronized progesterone may be better tolerated and have a more favorable impact on the lipid profile thanmedroxyprogesterone does (de Lignières, 1999; Fitzpatrick, Pace, & Wiita, 2000).

Thanks for the info Peky. I've seen that but it still leaves a lot of open questions.  I'd have to see the study itself and review the methodology, sample size, assumptions, controls, etc., to really take any information from it.  There is a lot of information out there that is spread as the "absolute gospel" by the medical community and comes from extrapolations of studies and data that may not be very comparable. 

For instance, most of the benefits/harms from HRT comes from the WHI (Womens Health Initiative) which only looked at women taking Premarin or Premarin with medroxyprogesterone acetate.  There are still a lot of holes in the full understanding of endocrinology and I'm always open to looking at something that someone may have stumbled across. After all, it wasn'ta big shot gastroenterologist that discovered that the bacteria h. pylori caused over 95% of all stomach ulcers  and that it could be cured with a cocktail of pink bismuth and antibiotics. It was an Australian family practice doctor that figured that out...