Quote from: NotThereYet on December 30, 2012, 07:03:35 PM
@Hippolover
Pardon my ignorance but could you elucidate on Spiro and why it is bad to skip(and double-dose)?
Both are equally bad to miss. Don't miss them if you can help. But unlike estradiol, spiro is not stored in your body's fat. It's not stored at all. It works by filling up cell's receptors for testosterone. Picture this:
Hold your hand up like you're going to draw a thanksgiving turkey with it. This hand represents a cell in your body that has a receptor to testosterone. Now take your other hand and slide your fingers in between each other so that both hands are locked. This hand represents the hormone testosterone. This model is similar--a dumbed down version of course--to how cell receptors work in the body.
In your body your cells have receptors that respond to hormones. When a testosterone locks up within a cell to the appropriate receptors the cell knows to do "manly" things (lol!). Spironolactone's structure so closely resembles the structure of testosterone that it fills in the cell's receptors before your body's testosterone can fill them in. Thus, "spiro" blocks testosterone's ACTION in the body. Spiro alone will not lower T levels--this is according to my doctor. I don't know if she is right by saying that spiro alone will do nothing to lower total T levels. But she does have the Ph.D. not me! Lol.
But anyway, spiro has a short life span in the body though. Its not stored anywhere. If you miss a day, or more, the receptors for testosterone are no longer blocked, meaning that testosterone can resume sending "manly" signals to your cells.
Hope this explanation helps. My doctor used the same method to explain it to me. I like to know how things work. So I asked her and she told me. Your doctor will likely do the same.
Oh--and estradiol works the same way as testosterone. Each cell has an appropriate receptor for it. Its stored in the fat though and is released much more slowly. Thus it last in the body much longer. As it is released it fits into the receptor's of cells in your body. My doctor says estradiol is more potent that testosterone. I would agree with her, though many on here will strongly disagree with that. My doctor is old school and is of the mind that Estradiol SUPPRESSES Testosterone Spironolactone BLOCKS Testosterone. She wanted to start me out on just Estradiol; I had to talk her into giving me spiro too.