Of course it does. Everything starts at the first second. But of course, it's slower in the beginning, and when and how much it accelerates varies a lot. Typically you will start to really notice it around the 3-6-month mark, and it should be really obvious after a couple of years. But. That's all shoulds. No wills. It all varies greatly from person to person. On top, if you're skinny, it will be more subtle and appear slower. And if you gain weight during HRT, it should be more apparent.