I have recently started taking 17 b estradiol micronized. What is the proper way to take it sub lingual?. I know i have to place it under my tongue and let it dissolve. Do i have to wait for all the blue saliva, under my tongue to disappear before i swallow?

I've noticed with mine it will eventually just kinda dissolve away.  However, different brands seem to dissolve better then others and one that I had became a horrible blue paste.. eww.. so that month I was just swallowing them.  I did also happen to have an endo check up and noticed the E levels did go down slightly vs when I took them sublingually, but not much to really affect anything.

I tend to wait about 30 seconds and check if most of it's dissolved. Some times it doesn't completely dissolve, so I just roll my tongue beneath  my lower lip and smoosh it until it's more granular. That usually does the trick. It's hard to keep it all beneath my tongue when I do this, but I don't think it's really a big deal.

Also, if you're being checked by your endo regularly (which is ~2-3 months for me), they'll likely prescribe a higher dose depending on the development of your levels. So even if you decide to just swallow the pill(s), your prescription can be increased to counter the reduction in effectiveness relative to taking them sublingaully (assuming your e is lower than it should be).

Well, place it under the middle of your tongue and then just build a lot of saliva. It helps.