Oh my God, YES!!!
The very first day that I was on estrogen was seriously the best day of my entire life. I don't know what it did to the pleasure-receptors in my head, but for some reason I just got an absolute explosion of pleasure from EVERYTHING that I did that day. Food tasted better, music practically made me cry out in sheer delight because suddenly it was so beautiful, and every touch and every sensation just felt like the BEST thing ever! It felt like half of the pleasure-receptors in my brain had been shut off for my entire life, and were just now waking up for the first time.
That feeling only lasted a couple of days, but I still have gained something that I just never had before as a guy... mental clarity. It's a feeling that the thoughts in my head are finally right, and that I can finally, for the first time in my entire life, feel real joy, and real pleasure, and real sadness, and real pain. As a guy, I just felt emotionally brain-dead, like my mind just wasn't working. I felt pain, but never enough to cry. I felt joy, but it always felt muted. Whereas on estrogen, suddenly it is just working! It's like my mind, and the feelings that I get, finally belong to me for the first time in my entire life, and aren't filtered through the muting of testosterone.
I was not expecting these unbelievable mental changes. I was only really expecting the physical changes, slow and pretty much unnoticeable. But it did NOT happen that way. My mind just COMPLETELY changed when I started HRT. I had never felt like this before. I didn't even know it was POSSIBLE to feel like this. And that was the instant that I finally, for 100% sure, and not just based on theories and narratives and what-ifs, knew that I really was transgender. Because when I finally started taking estrogen, for the first time in my entire life, I finally felt like my mind was working right, and that my true self was finally allowed to be unleashed, freed from the mental prison that she'd been locked up in for 14 years before that.
So yeah... it really is an unbelievable experience. I'm not saying that you'll necessarily experience the same extreme highs that I have felt, but the possibility is definitely there. It's life-changing stuff. It's reached the point where I can't even imagine going back to the way my life was before.