I wear thongs all the time, almost exclusively, but I do love cute little boy shorts too... I rarely, if ever wear normal panties unless I am wearing something flowing (see my avatar pic lol) and g-strings are just uncomfortable...
I wear a lot of stretch velvet and other fabrics that hug my figure, so wearing anything but a thong just shows A LOT of panty line.... then again, in the winter, I wear a slip under my skirt and probably boy shorts and sometimes hot pants lol
Anyway, I don't find them uncomfortable at all any more, but I do recall having to force and train myself not to try to pick at them for a few months when I first started wearing them... lol