I'm midway passed two weeks into HRT, myself. I was on spiro alone for about a week then after that, the E injections, but I get estradiol valerate IM weekly, self injected. Sometimes an endo will do low dose of one with the other med to see how they work together, sometimes just the one unless there is a reason for the other one. They should know what to look for in your blood panel work, so trust they got a reason. If in doubt, ask them 🙂 Also, welcome to the club, it only gets better from here 🙂