It think is is pretty well established that hormonal levels in the body affect the way we perceive the world, and our behavior. Look at how teenaged boys and girls act during puberty; PMS; female and male menopause.
When my mom had an undiagnosed adrenal carcinoma, she at times raged from the skewed hormone levels in her body.
For me, estradiol therapy opened my mind to a new understanding of myself. Even though I am largely off hormones, those psychological changes remain.